Results 61 to 70 of about 226,123 (296)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Pepper Harvest Mechanism

, 2020
Due to increased food need, plant cultivation issue has started to come up more often. As in all stagesof plant cultivation, the importance of harvesting is also increasing. Due to the consequences of shifting theworkforce to different areas in the developing world, tools and machines manufactured for use in agricultureneed to be mechanized with ...
Tekgüler, Ali, Karaköse, Tuğba
openaire   +1 more source

Comparison between Manual Harvesting and Mechanical Harvesting

Journal of Scientific Research and Reports
This paper presents a thorough analysis of the differences between human and automated harvesting techniques in agriculture, including their categorization, impacts, difficulties, costs, and potential future developments. Manual harvesting, which involves labor-intensive methods, enables meticulous handling and yields top-notch product.
Pargi Sanjay J., Pankaj Gupta, P. R. Balas, V. U. Bambhaniya   +3 more
openaire   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

On energy harvesting from ambient vibration

, 2006
Future MEMS devices will harvest energy from their environment. One can envisage an autonomous condition monitoring vibration sensor being powered by that same vibration, and transmitting data over a wireless link; inaccesible or hostile environments are
Stephen, N.G.
core   +1 more source

Date harvest mechanization

California Agriculture, 1966
Research started in 1961 by agricultural engineers of USDA and University of California has led to commercial acceptance of mechanical harvesting methods with resulting labor and cost savings for California date growers. About 65% of the 1965–66 date crop is expected to be harvested with the aid of various mechanical systems that can reduce labor ...
R Perkins, G Brown
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Over-the-Row Mechanical Harvest of Cider Apples (Malus domestica Borkh.)

Horticulturae
The single greatest annual production cost for an established cider apple (Malus domestica Borkh.) orchard is the labor required to hand harvest. Reducing harvest labor time may increase the appeal and profitability of growing cider apples.
Seth Brawner, Aidan Kendall, Lee Kalcsits, Carol Miles   +3 more
doaj   +1 more source

The Status of Labor-Saving Mechanization in Fruits and Vegetables [PDF]

The objective of this paper is to examine the status of labor-saving mechanization in U.S. fruit and vegetable harvesting. Fruit and vegetable harvest mechanization has several potential advantages: reduced harvest costs, eliminate problems associated ...
Wallace E. Huffman
core  

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source