Results 121 to 130 of about 230,916 (283)

Increasing Permittivity and Mechanical Harvesting Response of PVDF-Based Flexible Composites by Using Ag Nanoparticles onto BaTiO₃ Nanofillers. [PDF]

Nanomaterials (Basel), 2022
Horchidan N, Ciomaga CE, Curecheriu LP, Stoian G, Botea M, Florea M, Maraloiu VA, Pintilie L, Tufescu FM, Tiron V, Rotaru A, Mitoseriu L.   +11 more
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Mechanical harvesting of oil olives by trunk shaker with a reversed umbrella interceptor

Advances in Horticultural Science, 2012
Trunk shakers are primarily used for the mechanical harvesting of oil olives in intensive orchards. The objective of this trial was to determine the efficiency of mechanical harvesting of olives with a self-propelled trunk shaker with a reversed umbrella
Claudio Di Vaio, N. Marallo, S. Nocerino, F. Famiani   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Physical and Mechanical Properties of Palm Oil Frond and Stem Bunch for Developing Pruner and Harvester Machinery Design [PDF]

, 2013
A development of oil palm pruner and harvester machinery design implemented in the field still faces a problem due to the lack of effective and efficient design which is need to be solved.
Hamdi, Mayulu, P.A.S., Radite, Yazid, Ismi Intara   +2 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Nonlinear MEMS Mechanism for Energy Harvesting from Mechanical Vibrations

, 2011
The aim of this paper is the realization of a novel bistable U-shaped micro-electro-mechanical system to efficiently harvest energy from ambient vibrations. The classical approach is based on vibrating mechanical bodies (linear systems) that allow for collecting energy through the adoption of smart materials, magnetic or electrostatic solutions.
ANDO', Bruno, BAGLIO, Salvatore, TRIGONA, CARLO   +2 more
openaire   +4 more sources

Optimal energy-harvesting cycles for load-driven dielectric generators in plane strain

, 2014
The performances of energy harvesting generators based on dielectric elastomers are investigated. The configuration is of a thin dielectric film coated by stretchable electrodes at both sides.
Bortot, E., deBotton, G., Gei, M., Springhetti, R.   +3 more
core   +1 more source