Results 151 to 160 of about 56,498 (290)

A Bovine Model for Detecting High Intensity Transient Signals Originating from Mechanical Heart Valves

open access: bronze, 2000
Jeff L. Conger   +8 more
openalex   +1 more source

ATF3 Deficiency Exacerbates Ageing‐Induced Atherosclerosis and Clinical Intervention Strategy

open access: yesAdvanced Science, EarlyView.
Targeting ATF3 with terazosin to against VSMC Senescence and atherosclerosis. TZ reduces the binding affinity of YTHDF2 to Atf3 mRNA, while enhancing mRNA stability. ATF3 promotes Atg7 transcription, enhancing autophagy. ATG7 binds to ATF3 in the cytoplasm, facilitating ATF3 translocation to the nucleus and establishing positive feedback. By modulating
Hao Nie   +11 more
wiley   +1 more source

A Human Engineered Heart Tissue‐Derived Lipotoxic Diabetic Cardiomyopathy Model Revealed Early Benefits of Empagliflozin

open access: yesAdvanced Science, EarlyView.
This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai   +9 more
wiley   +1 more source

Tissue and mechanical heart valves.

open access: yesAnnals of cardiothoracic surgery, 2015
Beth Croce   +2 more
openaire   +3 more sources

Refractive Index‐Corrected Light‐Sheet Microscopy for Macro‐View Cardiovascular Imaging

open access: yesAdvanced Science, EarlyView.
A refractive index‐corrected light‐sheet fluorescence microscopy system enables macro‐view cardiovascular imaging across organs, adapting to refractive index variations from different optical clearing protocols. By integrating axial sweeping, multi‐view imaging, and a sealed chamber, it extends the field of view, enhances isotropy, and improves safety.
Enbo Zhu   +13 more
wiley   +1 more source

BCG‐Derived Outer Membrane Vesicles Induce TLR2‐Dependent Trained Immunity to Protect Against Polymicrobial Sepsis

open access: yesAdvanced Science, EarlyView.
B‐OMVs, nanoscale vesicles derived from BCG, are identified as effective and safe inducers of trained immunity that protect against sepsis. Through TLR2‐mediated metabolic and epigenetic reprogramming of hematopoietic stem cells, B‐OMVs enhance inflammatory response and phagocytic activity.
Yuan Gong   +16 more
wiley   +1 more source

Fast Charging and High Power Ionogel‐Based Rain Energy Harvester

open access: yesAdvanced Science, EarlyView.
This work presents a highly adhesive ionogel‐based rain energy harvester, which enhances energy harvesting stability and efficiency (6.77%). This device is flexible, transparent, and exhibits exceptional electrical outputs, generating 502 µA and 204 V with every individual tap water droplet, while also showing promise in droplet energy harvesting and ...
Ruoxuan Ye   +7 more
wiley   +1 more source

Highly Oriented Bio‐Mimetic Hydrogels by Calendering

open access: yesAdvanced Science, EarlyView.
A facile and scalable organogel‐assisted calendering strategy is proposed to prepare bio‐mimetic anisotropic polyvinyl alcohol (PVA) hydrogels. By employing a combination of shearing and annealing during calendering, PVA chains are aligned in the calendering direction, while the compression in thickness facilitates the formation of a nacre‐like ...
Zhanqi Liu   +15 more
wiley   +1 more source

Dual‐Graded Microstructure Engineering for Flexible Piezoresistive Sensors with High Sensitivity and Broad Linear Range in Physiological Monitoring

open access: yesAdvanced Science, EarlyView.
A flexible piezoresistive pressure sensor with dual‐graded microstructures achieves both high sensitivity (69.8 kPa⁻¹) and a broad linear range up to 300 kPa (R2 = 0.997). Synergizing structural deformation and tunneling conduction, it enables rapid, stable, and accurate detection of subtle physiological signals, offering a scalable and cost‐effective ...
Ningning Bai   +11 more
wiley   +1 more source

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