Results 91 to 100 of about 5,542,649 (397)

Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2015
Background Patients with mechanical heart valves (MHV) require warfarin to prevent thromboembolism. Although dabigatran was as effective as warfarin for stroke prevention in atrial fibrillation when compared with warfarin in patients with MHV, the study ...
I. Jaffer, A. Stafford, J. Fredenburgh, R. Whitlock, N. Chan, J. Weitz   +5 more
semanticscholar   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Statistics of heart failure and mechanical circulatory support in 2020

Annals of Translational Medicine, 2020
Heart failure is increasing in prevalence, with approximately 26 million patients affected worldwide. This represents a significant cause of morbidity and mortality.
Robert E. Bowen, T. Graetz, D. Emmert, M. Avidan   +3 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Changes and classification in myocardial contractile function in the left ventricle following acute myocardial infarction [PDF]

, 2017
In this research, we hypothesized that novel biomechanical parameters are discriminative in patients following acute ST-segment elevation myocardial infarction (STEMI).
Aderhold, Andrej, Berry, Colin, Gao, Hao, Husmeier, Dirk, Luo, Xiaoyu, Mangion, Kenneth   +5 more
core   +1 more source

Mechanisms of Ischemic Heart Injury

Cells, 2022
Ischemic heart disease is a leading cause of morbidity and mortality worldwide [...]
openaire   +3 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Bone mechanical loading reduces heart rate and increases heart rate variability in mice

Bone Reports
Cardiovascular disease and osteoporosis are clinically associated. Bone adapts to mechanical forces by altering its overall structure and mass. In response to mechanical strain bone cells release signaling molecules and activate the nervous system.
Julian A. Vallejo, Mark Gray, Jackson Klump, Andrew Wacker, Mark Dallas, Mark L. Johnson, Michael J. Wacker   +6 more
doaj   +1 more source

Spatiotemporal Organization of Electromechanical Phase Singularities during High-Frequency Cardiac Arrhythmias

Physical Review X, 2022
Ventricular fibrillation (VF) is a life-threatening electromechanical dysfunction of the heart associated with complex spatiotemporal dynamics of electrical excitation and mechanical contraction of the heart muscle.
A. Molavi Tabrizi, A. Mesgarnejad, M. Bazzi, S. Luther, J. Christoph, A. Karma   +5 more
doaj   +1 more source

Topological modes bound to dislocations in mechanical metamaterials

, 2015
Mechanical metamaterials are artificial structures with unusual properties, such as negative Poisson ratio, bistability or tunable vibrational properties, that originate in the geometry of their unit cell.
A Stern, BG Chen, Bryan Gin-ge Chen, C Calladine, CL Kane, E Prodan, Jayson Paulose, JC Maxwell, JCY Teo, K Sun, M Schenk, S Babaee, S Shan, T Tachi, V Juričić, V Vitelli, Vincenzo Vitelli, Y Ran, ZY Wei   +18 more
core   +1 more source