Results 131 to 140 of about 5,542,649 (397)

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Neurohumoral and mechanical factors in the modulation of left ventricular mass [PDF]

open access: yes
The goals for the research were to define, describe, and study those neuroendocrine and mechanical mechanisms that may play a role in the initiation and maintenance of an increase in, or cause regression of, the mass of the left ventricle.
Franklin, Eleanor I.   +1 more
core   +1 more source

Human behaviors: a threat for mosquito control?

open access: yes, 2015
Community involvement and the preventive behavior of households are considered to be at the heart of vector-control strategies. In this work, we consider a simple theoretical model that enables us to take into account human behaviors that may interfere ...
Dumont, Y., Thuilliez, J.
core   +3 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

A modeling framework for contact, adhesion and mechano-transduction between excitable deformable cells

open access: yes, 2017
Cardiac myocytes are the fundamental cells composing the heart muscle. The propagation of electric signals and chemical quantities through them is responsible for their nonlinear contraction and dilatation. In this study, a theoretical model and a finite
Gizzi, Alessio   +2 more
core   +1 more source

Heart-lung interactions during mechanical ventilation: the basics.

open access: yesAnnals of Translational Medicine, 2018
The hemodynamic effects of mechanical ventilation can be grouped into three clinically relevant concepts. First, since spontaneous ventilation is exercise.
S. S. Mahmood, M. Pinsky
semanticscholar   +1 more source

Changes in Pulmonary Hemodynamics Resulted From Long-Term Mechanical Heart Support

open access: hybrid, 2023
D. V. Doronin   +6 more
openalex   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy