Results 81 to 90 of about 8,047,163 (238)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Nanomechanical properties of neutron-irradiated concrete

Acta Polytechnica CTU Proceedings
Concrete exposed to irradiation from nuclear reactor undergoes atomic-level degradation due to the influence of neutrons, secondary gamma rays, and associated gamma heating. The radiationinduced damage decreases the mechanical properties of the concrete
Ondřej Libera, Jiří Němeček, Patricie Halodová, Zbyněk Hlaváč, Jiří Němeček   +4 more
doaj   +1 more source

Recent Progress of Metal–Air Batteries—A Mini Review

Applied Sciences, 2019
With the ever-increasing demand for power sources of high energy density and stability for emergent electrical vehicles and portable electronic devices, rechargeable batteries (such as lithium-ion batteries, fuel batteries, and metal−air batteries)
Chunlian Wang, Yongchao Yu, Jiajia Niu, Yaxuan Liu, Denzel Bridges, Xianqiang Liu, Joshi Pooran, Yuefei Zhang, Anming Hu   +8 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

The effect of alkalisation on the mechanical properties of natural fibres [PDF]

, 2008
A study on the effect of alkalisaton using 3% NaOH solution was carried out on Flax, Kenaf, Abaca and Sisal to observe the impact that the common pre-treatment process has on fibre mechanical properties.
Symington, Mark C., David-West, Opukuro S., Pethrick, Richard A., Banks, William M., Thomason, J.L.   +4 more
core   +3 more sources

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Peculiar Spatiotemporal Behavior of Unstable Plastic Flow in an AlMgMnScZr Alloy with Coarse and Ultrafine Grains

Metals, 2017
The work addresses the effects of nanosize particles and grain refinement on the patterns of stress serrations and kinematics of deformation bands associated with the Portevin–Le Chatelier instability of plastic flow.
Daria Zhemchuzhnikova, Mikhail Lebyodkin, Tatiana Lebedkina, Anna Mogucheva, Diana Yuzbekova, Rustam Kaibyshev   +5 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source