Results 91 to 100 of about 1,446,577 (354)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Measurement of mechanical and thermophysical properties of dimensionally stable materials for space applications [PDF]

Mechanical, thermal, and physical property test data was generated for as-fabricated advanced composite materials at room temperature (RT), -150 and 250 F.
Misra, Mohan S., Rawal, Suraj P.
core   +1 more source

Some general aspects of thin-shell wormholes with cylindrical symmetry [PDF]

, 2010
In this article we study a general class of non-rotating thin-shell wormholes with cylindrical symmetry. We consider two physically sound definitions of the flare-out condition and we show that the less restrictive one allows for the construction of ...
Eiroa, Ernesto F., Simeone, Claudio
core   +3 more sources

Mycobacterium tuberculosis sulfurtransferase SseA is activated by its neighboring gene product Rv3284

FEBS Letters, EarlyView.
Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli, Alex Fissore, Edoardo Salladini, Eleonora Raccuia, Simonetta Oliaro‐Bosso, Alessia Ruggiero, Rita Berisio, Milagros Medina, Adrian Velazquez‐Campoy, Salvatore Adinolfi, Mauro Marengo   +10 more
wiley   +1 more source

Process for improving mechanical properties of epoxy resins by addition of cobalt ions [PDF]

, 1984
A resin product useful as an adhesive, composite or casting resin is described as well as the process used in its preparation to improve its flexural strength mechanical property characteristics.
St.clair, A. K., Stoakley, D. M.
core   +1 more source

Archaeal protein containing domain of unknown function 2193 undergoes oligomeric reconfiguration upon iron–sulfur cluster binding

FEBS Letters, EarlyView.
This work presents the characterization of MvoDUF2193, a Methanococcus voltae (Mvo) protein from the domain of unknown function (DUF) 2193 family. We demonstrate that MvoDUF2193 binds a single [4Fe–4S] cluster per subunit and that cluster occupancy regulates the transition from an apo tetramer to a [4Fe–4S] monomeric form. This structural transition is
Emily M. Dieter, James Larson, Monika Tokmina‐Lukaszewska, Jin Xiong, Jared Green, Yisong Guo, William E. Broderick, Brian Bothner, Joan B. Broderick   +8 more
wiley   +1 more source

Materials data handbook: Aluminum alloy 5456 [PDF]

A summary of the materials property information for aluminum alloy 5456 is presented. The scope of the information includes physical and mechanical property data at cryogenic, ambient, and elevated temperatures.
Muraca, R. F., Whittick, J. S.
core   +1 more source

Nitrogen retention/enrichment of 316LN austenitic stainless steel welds [PDF]

, 2006
The development of nitrogen enriched austenitic stainless steels has been a source of recent interest due to the abundant availability of nitrogen and by the manner in which nitrogen contributes several beneficial material property effects over a wide ...
Galloway, Alexander, McPherson, Norman
core  

Layered co-continuous structure in bone scaffold fabricated by laser additive manufacturing for enhancing electro-responsive shape memory properties

Journal of Materials Research and Technology
Porous scaffold based on electro-responsive shape memory polymers (ESMPs) possesses great potential applications in minimally invasive surgery for bone defect repair because it provides the ability for remote control and internal heating.
Cijun Shuai, Wentao Xu, Haofan He, Feng Yang, Jinglin Liu, Pei Feng   +5 more
doaj  

Change of Deformation and Flow Characteristics in a Fracture of Sedimentary Rocks Under Different Temperature and Confining Pressure Conditions

Journal of MMIJ, 2017
It is of significant importance to safely isolate the radioactive wastes from the human environments. Entombment of the wastes in deep subsurface may be a plausible solution on this issue, and will be adopted in the countries where the nuclear power ...
Naoki KINOSHITA, Hideaki YASUHARA
doaj   +1 more source