Results 131 to 140 of about 1,446,577 (354)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

open access: yesMolecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez   +17 more
wiley   +1 more source

A preliminary mechanical property and stress corrosion evaluation of VIM-VAR work strengthened and direct aged Inconel 718 bar material [PDF]

open access: yes
This report presents a preliminary mechanical property and stress corrosion evaluation of double melted (vacuum induction melted (VIM), and vacuum arc remelted (VAR)), solution treated, work strengthened and direct aged Inconel 718 alloy bar (5.50 in ...
Montano, J. W.
core   +1 more source

Mechanical end joint system for structural column elements [PDF]

open access: yes, 1982
A mechanical end joint system, useful for the transverse connection of strut elements to a common node, comprises a node joint half with a semicircular tongue and groove, and a strut joint half with a semicircular tongue and groove.
Bush, H. G., Wallsom, R. E.
core   +1 more source

Electro-Mechanical Simulation of Switching Characteristics for Nanoelectromechanical Memory

open access: yes, 2009
The static switching properties and readout characteristics of proposed high-speed and nonvolatile nanoelectromechanical (NEM) memory devices are investigated By conducting a three-dimensional finite element mechanical simulation combined with an ...
Arai, T   +6 more
core   +1 more source

The NBS: Processing/Microstructure/Property Relationships in 2024 Aluminum Alloy Plates [PDF]

open access: yes
As received plates of 2024 aluminum alloy were examined. Topics covered include: solidification segregation studies; microsegregation and macrosegregation in laboratory and commercially cast ingots; C-curves and nondestructive evaluation; time ...
Boettinger, W. J.   +4 more
core   +1 more source

Lower-curing-temperature PMR polyimides [PDF]

open access: yes
Partial substitution of a p-aminostyrene end-cap for the monomethyl ester of 5-norbornene-2, 3-dicarboxylic acid lowered the final cure temperature of typical PMR resins from 600 F to 500 F.
Delvigs, P.
core   +1 more source

Materials data handbook: Aluminum alloy 7075 [PDF]

open access: yes
A summary of the materials property information on aluminum alloy 7075 is presented. The scope of the information includes physical and mechanical properties of the alloy at cryogenic, ambient, and elevated temperatures.
Muraca, R. F., Whittick, J. S.
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte   +10 more
wiley   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

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