Results 151 to 160 of about 1,446,577 (354)

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

Characterization of a reversible-assembly mechanical metamaterial with an adjustble mechanical property

Jixie qiangdu
Lattice structures have become a research highlight in the fields of aviation, aerospace and automobile because of its high specific strength and stiffness.
WU Qi, YANG Yu, LU Yifei, BAO Panpan, WANG Zhigang   +4 more
doaj  

White-metal bearing alloys: mechanical properties at different temperatures and service tests

, 1933
H.K. Herschman, John L. Basil
openalex   +1 more source

A Description of the Iceberg Aircraft Carrier and the Bearing of the Mechanical Properties of Frozen Wood Pulp Upon Some Problems of Glacier Flow [PDF]

, 1948
M. F. Perutz
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Optimization of an oxide dispersion strengthened Ni-Cr-Al alloy for gas turbine engine vanes [PDF]

The investigation was carried out to determine the optimum alloy within the Ni-16Cr-Al-Y2O3 system for use as a vane material in advanced aircraft gas turbine engines.
Grierson, R., Klarstrom, D. L.
core   +1 more source

Preparation and properties of pure iron alloys: I. Effects of carbon and manganese on the mechanical properties of pure iron

, 1922
R. P. Neville, J. R. Cain
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The Relation Between the Mechanical Properties and Draw Ratio

, 1957
Tatsuro Kawaguchi
openalex   +2 more sources

THE EFFECT OF POLYPHOSPHATES AND MAGNESIUM ON THE MECHANICAL PROPERTIES OF EXTRACTED MUSCLE FIBERS [PDF]

, 1956
Emil Bozler
openalex   +1 more source