Results 111 to 120 of about 448,246 (218)

Beyond Visual Observations: Establishing the Mechanical Stability Threshold of Nanothin Polyethylene Layers. [PDF]

Membranes (Basel)
Lemus-Solorio A, Ramos-Estrada M, Vásquez-García SR, Rivera JL.   +3 more
europepmc   +1 more source

Investigating the mechanical stability of flexible metal-organic frameworks. [PDF]

Commun Chem, 2023
Son FA, Fahy KM, Gaidimas MA, Smoljan CS, Wasson MC, Farha OK.   +5 more
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Two-dimensional material-polymer hybrid membranes for enhanced mechanical stability and environmental remediation. [PDF]

Discov Nano
Talreja N, Chauhan D, Ramalinga Viswanathan M, Srituravanich W, Ashfaq M.   +4 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Mechanical stability of the interaction between a lower-limb rehabilitation exoskeleton and the user's body during functional tasks. [PDF]

Front Bioeng Biotechnol
Squartecchia S, Rabuffetti M, Lencioni T, Jonsdottir J, Marzegan A, Di Bello P, Ceroni I, Semprini M, Ferrarin M.   +8 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Achieving electrochemical and mechanical stability in a lightweight titanium alloy. [PDF]

Nat Commun
Zhang J, Zhang J, Xiao W, Luo X, Li X, Li N, Luo H, Liaw PK, Yang T.   +8 more
europepmc   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Anticondensation and Anti-icing Properties of Bendable Superhydrophobic Coatings with Enhanced Mechanical Stability. [PDF]

ACS Omega
Wu X, Mai J, Ye Z, Wei L, Pan Y.
europepmc   +1 more source