Results 131 to 140 of about 2,777,013 (241)

Nuclear deformation acts as a mechanical switch to drive breast cancer cell migration in a confined microenvironment. [PDF]

Theranostics
Wang M, Li X, Li B, Guo H, Zhao Z, Sun X, Yan W, Tan Y, Liu J, Chen Y, Li S, Li T, Dai X, Qin X, Liu Y.   +14 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Analysis of SWITCH Business Model - Recommandations on How to Further Design and Develop the Portfolio for Small University-Related Organsations

, 2014
SWITCH is a foundation operating in the Swiss ICT industry. Its core business consists of providing internet services to universities and research institutions in the university environment.
Hunziker, Kim, Baumgartner, Marco, Haldi, Silvan, Haller, Alain, Binkert, Andreas   +4 more
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

An NFATC4 phospho-switch links matrix stiffness to fibroblast fate. [PDF]

J Clin Invest
Frabotta RS, Tata PR.
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

n7gonzalez/switch: SWITCH 2.0

<p>This repository contains the SWITCH electricity planning model adapted for the REAM research lab.</p ...
jszinai, Rodrigo Henríquez-Auba, Mateo Torres-Ruiz, lpstreitmatter, Matthias Fripp, Martin, Ana Mileva, Josiah Johnston, Mark Seaborn, Natalia Gonzalez, Hector Rincon, Rangrang_Zheng, pesap, PatyHidalgo, Benjamin Maluenda   +14 more
core   +1 more source

Segmental flow responses in glaucomatous trabecular meshwork cells. [PDF]

Biomater Adv
Karimi A, Golchin H, Adamec M, Stanik A, Nandakumar P, Ganesan M, Aga M, White E, Kelley M, Acott T.   +9 more
europepmc   +1 more source