Results 71 to 80 of about 2,777,013 (241)

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Design of Measurement and Control System of Composite Fast Transfer Switch Based on PLC

open access: yesJournal of Harbin University of Science and Technology, 2017
The fast transfer switch gets more extensive application in the power supply system along with the raising of power supply requirement for continuity and reliability in the sensitivity loads such as in airport,military place,hospital and large scale ...
ZHANG Hong-yi, WEI Xin-lao
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

An innovative hybrid insulation switch to enable/disable electrical loads without overvoltages

open access: yesE3S Web of Conferences, 2017
This article describes an innovative project for the design of a low voltage switch to enable/disable electrical devices from an AC source, which is characterised by the absence of arc ignition.
Zajkowski Konrad
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

open access: yesFEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı   +4 more
wiley   +1 more source

Switch Engine Locomotive Class J3

open access: yes, 1893
Diagram of Switch Engine class J3 locomotive numbers 1081 & 1083 cylinder size 16" x 22"Class J3;1081 ...
Grant Locomotive Works;   +2 more
core  

Research on the lifetime of the switch and assumptions of increasing it [PDF]

open access: yesTransport, 2008
The switch is the most complicated and expensive component of a superstructure of the railway track. It requires particular attention and maintenance.
O. Slepakovas   +2 more
doaj   +2 more sources

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Switch Engine Locomotive Class I4

open access: yes, 1891
Diagram of Switch Engine class I4 locomotive numbers 1114-1116 cylinder size 18" x 24"Class I4;1114 ...
Mechanical Department;   +2 more
core  

Design and Simulation of a Low-Actuation-Voltage MEMS Switch

open access: yesEAI Endorsed Transactions on Energy Web, 2016
This paper presents a low-actuation-voltage micro-electro-mechanical system (MEMS) capacitive shunt switch which has a very large bandwidth (4 GHz to 24 GHz).
Yasser Mafinejad   +2 more
doaj   +1 more source

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