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Body Mass Index and Risk for COVID-19–Related Hospitalization, Intensive Care Unit Admission, Invasive Mechanical Ventilation, and Death — United States, March–December 2020
MMWR. Morbidity and mortality weekly report, 2021 Obesity* is a recognized risk factor for severe COVID-19 (1,2), possibly related to chronic inflammation that disrupts immune and thrombogenic responses to pathogens (3) as well as to impaired lung function from excess weight (4).Lyudmyla Kompaniyets, Alyson B Goodman, B. Belay, D. Freedman, M. S. Sucosky, S. Lange, A. Gundlapalli, T. Boehmer, H. Blanck +8 moresemanticscholar +1 more sourceEffectiveness of therapeutic heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital: RAPID randomised clinical trial
British medical journal, 2021 Objective To evaluate the effects of therapeutic heparin compared with prophylactic heparin among moderately ill patients with covid-19 admitted to hospital wards. Design Randomised controlled, adaptive, open label clinical trial. Setting 28 hospitals in M. Sholzberg, Grace H Tang, Hassan Rahhal, M. AlHamzah, L. B. Kreuziger, F. Áinle, F. Alomran, Khalid Alayed, M. Alsheef, Fahad AlSumait, C. E. Pompilio, C. Sperlich, S. Tangri, Terence Tang, Peter Jaksa, D. Suryanarayan, M. Almarshoodi, L. Castellucci, P. James, D. Lillicrap, M. Carrier, A. Beckett, C. Colovos, J. Jayakar, M. Arsenault, Cynthia Wu, K. Doyon, E. Andreou, Vera Dounaevskaia, E. Tseng, Gloria Lim, M. Fralick, S. Middeldorp, Agnes Y. Y. Lee, F. Zuo, Bruno R. da Costa, K. Thorpe, E. Negri, M. Cushman, P. Jüni, A. Laupacis, Yulia Lin, Andrew G. Day, B. Rochwerg, J. Abdulrehman, M. Gergi, R. Kondo, B. Piloto, Guilherme de Abreu Pereira, F. Valente, Ariel Fernando Villarroel Agreda, Pablo Andres Munoz Torres, Maíra Oliveira Moraes, Claudia de Lucena Moreira, Fernando Galassi Stocco Neto, Fabíola Vieira Duarte Baptista, J. A. Moreira, Augusto Séttemo Ferreira, Paula Frudit, G. Martínez, H. P. Souza, R. A. B. Neto, E. D’Amico, E. Padrão, Fernando Sarin da Mota e Albuquerque, G. Zangrossi, A. K. Kanasiro, Alissom Vitti Cincoto, Hugo de Souza Reis, Vitor Miyashiro Arias da Silva, A. Bellintani, Vivian dos Santos Pereira, Yohan Washington de Oliveira, B. J. Carvalho, Mariana de Souza Novaes, Henrique Brito Silveira, Gabriel César Alves de Avelar, Lara Bonanni Mota, Karina Caciola, Matheus de Arêa Leão Freire Marim, Tales Cabral Monsalvarga, Alexandre Salgado Blanco Santos, A. Haydar, Gabriella Seixas Sampaio Saraiva, Sabrina Correa da Costa Ribeiro, Julio Flavio Meirelles Marchini, Julio Cesar Garcia de Alencar, Ana Catharina de Seixas Santos, Caroline Millette, M. Lebeau, Céline Devaux, M. Boutin, T. N. Nguyen, L. Srour, Flávia De Angelis, Mariane Fugulin, A. Binnie, S. A. Bejaimal, A. Binding, Rosa M. Marticorena, G. Ginocchio, E. Kaplovitch, K. Rymaszewski, A. Raissi, Marcelo A. Falappa, Blair Ernst, A. Ali, M. Romano, Mobina Khurram, Christie Kim, A. Kapur, Michelle L. Edwards, Vidushi Swarup, B. Camilotti, J. Jani, Jeff Carter, Mark R. Gillrie, Davinder Sidhu, Traci Robinson, Krystina Stutely, I. Watpool, R. Porteous, K. Jao, Jean-Samuel Boudreault-Pedneault, Christopher E. Kandel, Maureen Taylor, Wei En Enoch Choo, Laura Parsons, Ann Dowbenka, Gitana Ramonas, S. Nikitin, Jeffery M. Patterson, M. Hnatiuk, Anca Tapardel, S. T. Lapner, T. Carpenter, Lori Rackel, Rebecca M. Cairns, Jessica Pinder, P. Anglin, Catherine McPherson, Liselle Chiverton, David Barbosa, Shany Loukiantchenko, Y. Shamiss, D. Tassy, S. Shivakumar, Mary M. Keating, Susan Pleasance, B. Kevane, S. Cullivan, N. Power, P. Doran, K. Leamy, Aoife C Kelly, Conor Moran, Mairead O’Connor, Aoife McDonnell, Roseanne Boyce, Faiza Sefroun, R. Hussain, P. Murray, A. Malara, B. Molloy, Meadbh O’Halloran, Emer Cunningham, J. Lambert, A. Cotter, B. Marsh, G. Sheehan, E. Muldoon, J. Woo, S. Gaine, Deirdre Morley, Farjah H Algahtani, I. Almaghlouth, Sondus I. Ata, Fai Alkhathlan, N. Khalil, Israa Mohamed Hussein, Mohammed Bashir, Ahmed S. Bahammam, A. Alsultan, H. Alkofide, Tariq M. Alhawassi, Abdulhadi M Alqahtani, E. Zayed, A. Alsughayir, Yacoub Abuzied, H. Alzahrani, Jawaher M Al-Otaibi, Haya S Alothaimeen, Noura Alzannan, Amer Al Homssi, H. Abid, S. Jones, S. Broaddrick, N. Jain, R. King, M. Jindal, Kristen M. Sanfilippo, Patty Nieters, Muhammad Hammad, Aleeswa Francis Benny, Tariq A. Hamdan, Suhaib Kamal Ahmed Elobaid, Ibrahim Khafagi, S. S. Ahmed, AbduleRehman AlEssaie, Shamma Alalawi, Khloud Bashir, Aysha Abdulla Salem Al Suwaidi, H. I. Ahmed, Mohamed Milad Ismail, El Mutasim Ahmed El Faki, Mercy Charles, Alice Dang, Gurpreet Lakhanpal, Dominic Lee, Prachi Ray, M. Naydenova, K. Wysocki, Aziz Jiwajee, Greg Wendling, Rebekah H. Boyle, E. Cornell, D. K. Mukaz +226 moresemanticscholar +1 more sourceEarly Active Mobilization during Mechanical Ventilation in the ICU.
New England Journal of Medicine, 2022 BACKGROUND
Intensive care unit (ICU)-acquired weakness often develops in patients who are undergoing invasive mechanical ventilation. Early active mobilization may mitigate ICU-acquired weakness, increase survival, and reduce disability.C. Hodgson, M. Bailey, R. Bellomo, K. Brickell, T. Broadley, H. Buhr, B. Gabbe, D. Gould, M. Harrold, A. Higgins, S. Hurford, T. Iwashyna, A. Serpa Neto, A. Nichol, Jeffrey J. Presneill, S. Schaller, Janani Sivasuthan, Claire J. Tipping, S. Webb, P. Young +19 moresemanticscholar +1 more sourceOxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation.
New England Journal of Medicine, 2022 BACKGROUND
Invasive mechanical ventilation in critically ill adults involves adjusting the fraction of inspired oxygen to maintain arterial oxygen saturation.M. Semler, J. Casey, B. D. Lloyd, P. G. Hastings, M. Hays, J. Stollings, K. Buell, J. Brems, E. T. Qian, K. Seitz, Li Wang, C. Lindsell, R. Freundlich, J. Wanderer, Jin-Hui Han, G. Bernard, W. Self, T. Rice +17 moresemanticscholar +1 more sourceHigh Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus‐2 (SARS‐CoV‐2) Requiring Invasive Mechanical Ventilation
Obesity, 2020 The COVID‐19 pandemic is rapidly spreading worldwide, notably in Europe and North America where obesity is highly prevalent. The relation between obesity and severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) has not been fully documented.A. Simonnet, M. Chetboun, J. Poissy, V. Raverdy, Jerome Noulette, A. Duhamel, J. Labreuche, D. Mathieu, F. Pattou, M. Jourdain +9 moresemanticscholar +1 more sourcePersonalized mechanical ventilation in acute respiratory distress syndrome
Critical Care, 2021 A personalized mechanical ventilation approach for patients with adult respiratory distress syndrome (ARDS) based on lung physiology and morphology, ARDS etiology, lung imaging, and biological phenotypes may improve ventilation practice and outcome ...P. Pelosi, L. Ball, Carmen S. V. Barbas, R. Bellomo, K. Burns, S. Einav, L. Gattinoni, J. Laffey, J. Marini, S. Myatra, M. Schultz, J. Teboul, P. Rocco +12 moresemanticscholar +1 more sourceDevelopment and validation of a reinforcement learning algorithm to dynamically optimize mechanical ventilation in critical care
npj Digital Medicine, 2021 The aim of this work was to develop and evaluate the reinforcement learning algorithm VentAI, which is able to suggest a dynamically optimized mechanical ventilation regime for critically-ill patients. We built, validated and tested its performance on 11,A. Peine, Ahmed Hallawa, J. Bickenbach, Guido Dartmann, L. Fazlic, A. Schmeink, G. Ascheid, C. Thiemermann, A. Schuppert, R. Kindle, L. Celi, G. Marx, L. Martin +12 moresemanticscholar +1 more source