Results 181 to 190 of about 13,496 (210)

Tracheostomy timing and weaning outcomes following prolonged mechanical ventilation. [PDF]

BMC Pulm Med
Ghiani A, Tsitouras K, Lutfi A, Barnikel M, Kempa AT, Kneidinger N.   +5 more
europepmc   +1 more source

Supratherapeutic drug concentration triggers: A novel data‐driven approach to assess their value for medication safety surveillance in intensive care

British Journal of Clinical Pharmacology, EarlyView.
Aims Electronic triggers (e‐triggers) are used as screening signals to detect potential adverse drug events (ADEs) and offer an effective system level approach for medication safety surveillance. Their clinical utility is typically evaluated through time‐consuming manual chart review by experts, limiting implementation.
Anne Paulien Langermans, Izak A. R. Yasrebi‐de Kom, Dylan Wayne de Lange, Nicolette Fransisca de Keizer, Joanna E. Klopotowska, on behalf of the RESCUE Study group, C. S. C. Bouman, E. N. van Roon, P. F. Schutte, J. ten Cate, D. van Balen, S. Hendriks, C. Lau, W. J. Vermeijden, A. Beishuizen, J. B. Masselink, P. E. Spronk, H. J. M. van Kan, P. W. de Feiter, E. J. Wils, A. Wieringa, A. J. Valkenburg, W. M. van den Bergh, M. H. Renes, W. Bult, E. de Jonge, M. Hoeksema, E. J. Wesselink, I. M. Purmer, B. E. Bosma, S. H. W. van Bree, H. J. W. Lammers, R. J. Bosman, E. J. F. Franssen, A. Karakus, M. Sigtermans, E. M. Kuck, D. A. Dongelmans, M. J. H. Aries, E. V. Uijtendaal, M. C. Reuland   +40 more
wiley   +1 more source

Safety and pharmacokinetics of mosliciguat, a new, inhaled soluble guanylate cyclase activator, in healthy adult subjects

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mosliciguat (BAY 1237592), the first soluble guanylate cyclase (sGC) activator in a dry powder inhaler (DPI), could potentially treat pulmonary hypertension with a more targeted delivery than systemic sGC stimulators. We report safety and tolerability of mosliciguat in healthy men.
Johannes Nagelschmitz, Soundos Saleh, Sandra Ligges, Melanie Seidel‐Greven, Eva Becker‐Pelster, Sylvia M. Nikkho, Stefanie Boxnick, Wolfgang Timmer   +7 more
wiley   +1 more source

Development of a nalmefene formulation suitable for a community‐use auto‐injector

British Journal of Clinical Pharmacology, EarlyView.
Aim Time to onset of reversal is critical when treating opioid‐induced respiratory depression and hypoxia. This study aimed to develop a formulation of the opioid antagonist nalmefene with an increased absorption rate and reduced time to onset of reversal following intramuscular administration. Methods Several absorption enhancers were screened in rats,
Alessandra Cipriano, Manjunath S. Shet, Hugh Huang, Ronnie Ortiz, Garth T. Whiteside, Glen Apseloff, Stephen C. Harris   +6 more
wiley   +1 more source

Exhalation-synchronous robotic abdominal compression for user-centered respiratory assistance and training in neurological patients. [PDF]

J Neuroeng Rehabil
Lee SY, Beom J, Hahn JO, Lim JY, Cho KJ.
europepmc   +1 more source

Outcomes of children after initiation of home mechanical ventilation via tracheostomy: a single center retrospective study. [PDF]

BMC Pulm Med
Kreger JE, Reiner MC, Ramsey AM, Hassan F, Filbrun AG, Nelson VS, Hershenson MB.   +6 more
europepmc   +1 more source

A case of long-term comprehensive rehabilitation culminated in weaning from a ventilator and regaining oral intake for a patient who underwent tracheostomy, mechanical ventilation, and alternative nutritional management because of type II respiratory failure after ascending aortic artificial vascular replacement. [PDF]

Jpn J Compr Rehabil Sci
Mizumoto T, Matsubara K, Kambayashi Y, Nomura T, Fukushima A, Ueki Y, Aida N.   +6 more
europepmc   +1 more source

Adaptive minute ventilation during intrahospital transport: study protocol for a randomized controlled trial. [PDF]

Trials
Zhu P, Wang J, Gui Y, Li F, Yuan Y, Sun P, Zhu H, Shi D, Liu J.   +8 more
europepmc   +1 more source

Outcomes of invasive mechanical ventilation in critically ill patients with interstitial lung disease: protocol for a systematic review and meta-analysis. [PDF]

BMJ Open
Kola N, Parker R, Hall A, Spencer LG, Fletcher SV, Welters ID, Johnston BW.   +6 more
europepmc   +1 more source