Results 231 to 240 of about 31,697 (329)

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

open access: yesAdvanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu   +11 more
wiley   +1 more source

Power to mechanical power to minimize ventilator-induced lung injury? [PDF]

open access: gold, 2019
Pedro Leme Silva   +3 more
openalex   +1 more source

PIEZO Force Sensing in Vascular Biology: An Explosion of New Knowledge, Concepts and Opportunity

open access: yesAdvanced Science, EarlyView.
Knowledge of the remarkable mechanical force sensing and electrically transducing PIEZO1 and PIEZO2 channels is discussed across vascular biology and its cell types from the embryonic to adult stages in health, disease and old age. How the channels work, relate to other factors and signal for tissue responses to mechanical forces is debated.
David J Beech
wiley   +1 more source

Cyclic Strain and Macrophage‐Mediated Transport Govern Micron‐Sized PM2.5 Translocation across the Air–Blood Barrier

open access: yesAdvanced Science, EarlyView.
Using a dynamic, tri‐culture air‐blood barrier model, this study reveals that macrophage‐mediated transport governs micron‐sized particle translocation under cyclic strain. The process is highly size‐dependent that 2 µm particles are transported by macrophages, 0.2 µm particles diffuse passively, and 5 µm particles are effectively blocked.
Yongjian Li   +3 more
wiley   +1 more source

Solid Additives for Spontaneously Spreading‐Processed Organic Photovoltaics

open access: yesAdvanced Science, EarlyView.
This work developed a spontaneous spreading process with solid additives for the fabrication of organic photovoltaics (OPVs). By regulating interfacial tension, the solid additives enable the formation of uniform films on the water surface. A remarkable power conversion efficiency of 16.4% is recorded in the OPVs using phenanthrene (PAT) as the ...
Huitong Deng, Qianqing Jiang, Dianyi Liu
wiley   +1 more source

Building‐Tailored Hierarchical Electrochromism with Optimized Control Strategies

open access: yesAdvanced Science, EarlyView.
This study addresses the material‐application disconnect in electrochromic smart windows by establishing a building‐centric paradigm. It develops a Prussian blue (PB)‐based electrochromic device (ECD) with four spectral states via dual mechanisms, and proposes two control strategies.
Shuangdui Wu   +6 more
wiley   +1 more source

From starting mechanical ventilation to ventilator-associated pneumonia, choosing the right moment to start antibiotic treatment

open access: gold, 2016
Paula Ramírez   +7 more
openalex   +1 more source

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