Results 291 to 300 of about 31,697 (329)

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft   +18 more
wiley   +1 more source

Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Tirzepatide: A peptide‐based GLP‐1/GIP receptor agonist, tested on L‐Arginine‐induced pancreatitis. Lipase/Amylase Levels: Initially elevated due to inflammation but normalized with Tirzepatide. Inflammatory Response: Reduction in pro‐inflammatory cytokines (IL‐6) and enhancement of anti‐inflammatory cytokines (IL‐4, IL‐10).
Razan Alawaji   +9 more
wiley   +1 more source

Revisiting the monocrotaline‐treated rat as a model of inflammatory lung disease: COVID‐19 and future pandemic threats?

open access: yesAnimal Models and Experimental Medicine, EarlyView.
In this review, the pathological, molecular, and cellular changes observed in the COVID‐19 lung are compared to those in the laboratory rat treated with monocrotaline (MCT). Similarities that reflect common changes associated with inflammation and endothelial cell dysfunction are observed in both states, leading to a lung pathology characterized by ...
Luke P. Kris   +3 more
wiley   +1 more source

Intranasal Wharton's Jelly‐Derived Mesenchymal Stem Cell Therapy, Alone or in Conjunction With Therapeutic Hypothermia, Alleviates Neonatal Hypoxic‐Ischemic Brain Injury in Mice

open access: yesAnnals of Neurology, EarlyView.
This study demonstrates that intranasal Wharton's jelly‐derived mesenchymal stem cell (WJ‐MSC) administration at 3 or 10 days post‐insult reduced the lesion size and sensorimotor impairment following neonatal hypoxic‐ischemic (HI) brain injury in mice. WJ‐MSCs expressed receptors for HI‐upregulated chemokines and migrated from the nasal cavity into the
Caroline G. M. de Theije   +9 more
wiley   +1 more source

Detecting Awareness in the Intensive Care Unit Using Functional Near‐Infrared Spectroscopy

open access: yesAnnals of Neurology, EarlyView.
Objective Signs of awareness after acute severe brain injury are critical for informing goals‐of‐care decisions, ranging from the continuation of aggressive life‐sustaining therapy to comfort‐focused end‐of‐life measures. However, awareness may go undetected in some critically ill patients when assessed using bedside behavioral neurological examination.
Karnig Kazazian   +10 more
wiley   +1 more source

Inhibition Characteristics of Methane/Air Explosions by Collaborative Inhibition Devices

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT With the advancement of the modernization and intensification of urban pipelines, the utility tunnels have become important public infrastructure in the new urban areas of our country. In case of a gas explosion accident, it will seriously endanger public safety. To reveal the mechanism of the collaborative effect of water mist and porous slip
Kang Cen   +5 more
wiley   +1 more source

Characterization of Lightweight Polymeric Honeycomb Structures for Use as Backsides in Glass‐Free PV Modules

open access: yesJournal of Applied Polymer Science, EarlyView.
This study evaluates PET‐ and PP‐based honeycomb sandwich composites with glass fiber‐reinforced skins as lightweight backsheets for photovoltaic modules. Mechanical, optical, and thermal properties are assessed. Glass fiber embedment quality influences strength and moisture resistance.
Nikolina Pervan   +8 more
wiley   +1 more source

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