Results 121 to 130 of about 2,815,350 (337)

The CDK12–BRCA1 signaling axis mediates dinaciclib‐associated radiosensitivity through p53‐mediated cellular senescence

open access: yesMolecular Oncology, Volume 19, Issue 4, Page 1265-1280, April 2025.
Dinaciclib blocks CDK12 activity, leading to downregulation of BRCA1, and probably other proteins involved in homologous recombination, promoting nonhomologous end joining. In this scenario, the presence of ionising radiation triggers a p53‐dependent senescent response that yields increased radiosensitivity. Pan‐cyclin‐dependent‐kinase (CDK) inhibitors
Natalia García Flores   +14 more
wiley   +1 more source

Equilíbrio no espaço: experimentação e modelagem matemática

open access: yesRevista Brasileira de Ensino de Física
A elaboração e realização de experimentos, associadas à interpretação dos resultados, construção e aplicação de conceitos e uso de recursos da informatica, constituem uma opção metodológica desafiadora no ensino de física dos dias atuais, considerando as
P.A. Pereira Borges   +2 more
doaj   +1 more source

NanoCMSer: a consensus molecular subtype stratification tool for fresh‐frozen and paraffin‐embedded colorectal cancer samples

open access: yesMolecular Oncology, Volume 19, Issue 5, Page 1332-1346, May 2025.
Consensus molecular subtypes (CMS1‐4) have been identified to study colorectal cancer heterogeneity and serve as potential biomarkers. In this study, we developed and evaluated NanoCMSer, a NanoString‐based classifier using 55 genes, optimized for FF and FFPE to facilitate the clinical evaluation of CMS subtyping.
Arezo Torang   +10 more
wiley   +1 more source

Lagrangian Mechanics on Generalized Lie Algebroids [PDF]

open access: yesarXiv, 2011
A solution for the Weinstein's Problem in the general framework of generalized Lie algebroids is the target of this paper. We present the mechanical systems called by use, mechanical (?; ?)-systems, Lagrange mechanical (?; ?)-systems or Finsler mechanical (?; ?)-systems and we develop their geometries.
arxiv  

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon

open access: yesMolecular Oncology, EarlyView.
Large multidimensional digital images of cancer tissue are becoming prolific, but many challenges exist to automatically extract relevant information from them using computational tools. We describe publicly available resources that have been developed jointly by expert and non‐expert computational biologists working together during a virtual hackathon
Sandhya Prabhakaran   +16 more
wiley   +1 more source

The Exponential Mechanism for Social Welfare: Private, Truthful, and Nearly Optimal [PDF]

open access: yesarXiv, 2012
In this paper we show that for any mechanism design problem with the objective of maximizing social welfare, the exponential mechanism can be implemented as a truthful mechanism while still preserving differential privacy. Our instantiation of the exponential mechanism can be interpreted as a generalization of the VCG mechanism in the sense that the ...
arxiv  

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