Results 41 to 50 of about 7,959 (256)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Dielectric Performance of Silica-Filled Nanocomposites Based on Miscible (PP/PP-HI) and Immiscible (PP/EOC) Polymer Blends

IEEE Access, 2021
This study compares different polymer-nanofiller blends concerning their suitability for application as insulating thermoplastic composites for High Voltage Direct Current (HVDC) cable application.
Xiaozhen He, Paolo Seri, Ilkka Rytoluoto, Rafal Anyszka, Amirhossein Mahtabani, Hadi Naderiallaf, Minna Niittymaki, Eetta Saarimaki, Christelle Mazel, Gabriele Perego, Kari Lahti, Mika Paajanen, Wilma Dierkes, Anke Blume   +13 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The impact of surface cracks and surface roughness in the performance of hard chromium coatings in cold rolling applications

Applied Surface Science Advances
Hard chrome plating is widely utilized in industrial applications due to its high hardness, wear resistance, corrosion resistance, and low friction. However, the mechanisms responsible for its exceptional tribological performance and strip cleanliness in
Zahra Ranjbar-Nouri, David Matthews, Henk Bolt, Matthijn de Rooij   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Characterization of mechanical damage in granite

Fracture and Structural Integrity, 2013
This paper aims to illustrate the use of infrared thermography as a non-destructive and non-contact technique to observe the phenomenological manifestation of damage in granite under unconfined compression. It allows records and observations in real time
Minh-Phong Luong, Mehrdad Emami
doaj  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Non-Smooth Multi-Objective Controller Synthesis for Test-Mass Actuation in Gravitational-Wave Detectors

Galaxies
This paper proposes a non-smooth controller optimization method and shows the results of ongoing research on the implementation of this method for gravitational-wave applications.
Sander K. Sijtsma, Pooya Saffarieh, Nathan A. Holland, Sil T. Spanjer, Wouter B. J. Hakvoort, Conor M. Mow-Lowry   +5 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source