Results 231 to 240 of about 11,573,862 (305)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Pathogenesis of tubercular retinal vasculitis: An ongoing quest. [PDF]

J Clin Tuberc Other Mycobact Dis
Putera I, La Distia Nora R, Rombach SM, van Hagen PM, Dik WA.   +4 more
europepmc   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Analytical multi-body approach for component selection and timing analysis in spring-actuated vacuum circuit breakers. [PDF]

Sci Rep
Baniasadi AA, Darijani H, Matin M.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Uncovering outer-sphere mechanisms governing chemoselectivity in copper-photocatalyzed ATRA reactions of CF₃SO₂Cl with alkenes. [PDF]

Chem Sci
Shiri F, Jamshidi M, Hadidi S, Stranger R, Ariafard A.   +4 more
europepmc   +1 more source

HAO-AVP: An Entropy-Gini Reinforcement Learning Assisted Hierarchical Void Repair Protocol for Underwater Wireless Sensor Networks. [PDF]

Sensors (Basel)
Hao L, Ma C, Ao J.
europepmc   +1 more source

Effective deep convolutional neural network with attention mechanism for Alzheimer disease classification. [PDF]

Front Radiol
Lakshmanan SK, Muthusamy M, Dhanaraj RK, Sureshkumar A, Sayeed MS, Mohamed MYN, Rathinam G.   +6 more
europepmc   +1 more source

Motion analysis and structural parameter optimization for nested multi-link transplanting mechanism of variable plant spacing transplanting machine. [PDF]

PLoS One
Kang J, Tian S, Liu S, Liu J, Fu Y, Wang H, Awais M.   +6 more
europepmc   +1 more source