Results 231 to 240 of about 2,474,961 (353)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Research on interdisciplinary measurement and evolutionary path in the field of ophthalmology. [PDF]

Front Ophthalmol (Lausanne)
Chunji L, Yuwei L, Fangyuan Z, Zihan N.
europepmc   +1 more source

TNF biology, pathogenic mechanisms and emerging therapeutic strategies [PDF]

, 2015
George D. Kalliolias, Lionel B. Ivashkiv
openalex   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

MicroRNAs: discovery, breakthrough, and innovation

Blood Science
Jia Yu, Fang Wang
doaj   +1 more source

Lateralised memory networks may explain the use of higher-order visual features in navigating insects. [PDF]

PLoS Comput Biol
Filippi G, Knight J, Philippides A, Graham P.   +3 more
europepmc   +1 more source

The Cell and Molecular Biology of Glaucoma: Mechanisms of Retinal Ganglion Cell Death

, 2012
Robert W. Nickells
openalex   +1 more source

The radical-pair mechanism as a paradigm for the emerging science of quantum biology [PDF]

, 2015
I. K. Kominis
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Stereocilium height changes can account for the calcium dependence of the outer-hair-cell bundle's resting state. [PDF]

PLoS One
Chatterjee R, Ó Maoiléidigh D.
europepmc   +1 more source