Results 231 to 240 of about 1,277,465 (314)

Activation of B1 B cells by F. tularensis atypical LPS depends on classical complement and C3a. [PDF]

PLoS Pathog
Melo G, Barbosa CHD, Magrini E, Garlanda C, Re F.   +4 more
europepmc   +1 more source

Explanation in the cognitive sciences and biology: mechanisms, laws, and their explanatory virtues

, 2013
Raoul Gervais
openalex   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

From Biocontrol to Synthesis: Innovative Progress of <i>Paenibacillus</i> in Mechanism Analysis, Gene Editing and Platform Construction. [PDF]

Int J Mol Sci
Yuan P, Zhu L, Song Z, Wang Y, Chen X.
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Spatial domain identification method based on multi-view graph convolutional network and contrastive learning. [PDF]

PLoS Comput Biol
Liang X, Xiao S, Ba L, Feng Y, Ma Z, Adilova F, Qi J, Jin S.   +7 more
europepmc   +1 more source

Viral hijacking of the nucleolar DNA-damage response machinery: a novel mechanism to regulate host cell biology

, 2019
Stephen M. Rawlinson, Tianyue Zhao, Ashley M. Rozario, Christina L. Rootes, Paul J. McMillan, Anthony W. Purcell, Amanda P. Woon, Glenn A. Marsh, Kim G. Lieu, Lin‐Fa Wang, Hans Netter, Toby D. M. Bell, Cameron R. Stewart, Gregory W. Moseley   +13 more
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Processed Transcript Insertion as a Novel Germline Mutational Mechanism in <i>BRCA1</i>-Associated Hereditary Breast Cancer. [PDF]

Cancers (Basel)
Bozsik A, Butz H, Grolmusz VK, Nagy P, Pócza T, Tóth E, Csernák E, Patócs A, Papp J.   +8 more
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source