Results 351 to 360 of about 10,501,738 (419)

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Author Correction: Targeting pleuro-alveolar junctions reverses lung fibrosis in mice. [PDF]

Nat Commun
Fischer A, Han W, Hu S, Mück-Häusl M, Wannemacher J, Kadri S, Lin Y, Dai R, Christ S, Su Y, Dasgupta B, Sardogan A, Deisenhofer C, Dutta S, Kadri A, Güney TG, Correa-Gallegos D, Mayr CH, Hatz R, Stoleriu MG, Lindner M, Hilgendorff A, Adler H, Machens HG, Schiller HB, Hauck SM, Rinkevich Y.   +26 more
europepmc   +1 more source

Hydrophobicity causes anomalous migration of cystine/glutamate antiporter SLC7A11 in SDS‐PAGE with low acrylamide concentration

FEBS Open Bio, EarlyView.
SLC7A11 frequently migrates faster in SDS‐PAGE. The present study found that the high hydrophobicity of SLC7A11 causes its anomalous migration in SDS‐PAGE with a low concentration of acrylamide gel. Replacing isoleucine with asparagine reduced hydrophobicity and restored its normal migration at 55 kDa, revealing the role of hydrophobicity and gel ...
Nsengiyumva Emmanuel, Qian He, Yixin Kang, Dianbao Zhang, Min Gao, Minglin Wang, Kexin Fan, Jingwen Xiong, Shaobo Wu, Botao Fa, Zhengtao Xiao, Yingfang Niu, Jun Yao, Yilei Zhang   +13 more
wiley   +1 more source

Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids. [PDF]

Nat Commun
Podgorski JM, Podgorski J, Abad L, Jacobs-Sera D, Freeman KG, Brown C, Hatfull GF, Luque A, White SJ.   +8 more
europepmc   +1 more source

METTL3 knockout accelerates hepatocarcinogenesis via inhibiting endoplasmic reticulum stress response

FEBS Open Bio, EarlyView.
Liver‐specific knockout of N6‐methyladenosine (m6A) methyltransferase METTL3 significantly accelerated hepatic tumor initiation under various oncogenic challenges, contrary to the previously reported oncogenic role of METTL3 in liver cancer cell lines or xenograft models. Mechanistically, METTL3 deficiency reduced m6A deposition on Manf transcripts and
Bo Cui, Silin Tu, Haibo Li, Zhancheng Zeng, Ruiqi Xiao, Jing Guo, Xiaoqi Liang, Chang Liu, Lijie Pan, Wenjie Chen, Mian Ge, Xiaofen Zhong, Linsen Ye, Huaxin Chen, Qi Zhang, Yan Xu   +15 more
wiley   +1 more source

Structural and Energetic Evidence Supports the Non-Covalent Phosphate Cyclization by the Class II Phospholipase D from <i>Loxosceles intermedia</i>. [PDF]

Toxins (Basel)
Gismene C, Ruggiero Bachega JF, Doherty DZ, Veiga SS, Arni RK, Hernández González JE.   +5 more
europepmc   +1 more source

SMND-309 activates Nrf2 signaling to alleviate acetaminophen-induced hepatotoxicity and oxidative stress. [PDF]

PLoS One
Dong Y, Jia R, Jiang Y, Li Q, Wang L, Ding W, Yan R, Qiu Y, Shi Z, Liu W, Wang J, Xu S, Li N.   +12 more
europepmc   +1 more source

Tandem mass tag-based quantitative proteomics and targeted hormone analysis reveal the response to insect herbivory stress in Ginseng (Panax ginseng, L.). [PDF]

PLoS One
Li H, Zhang L, Han X, Zhang Q, Liu G, Zhang G, Zhu Y, Liu H, Deng H, Liu S, Xi G.   +10 more
europepmc   +1 more source

Potential for micronuclear turnover through autophagy secretion pathway. [PDF]

MicroPubl Biol
Asami N, Yano S, Tsuruta F.
europepmc   +1 more source

Youthful insight: Nitrogen sequestration in larvae provides clues to coral bleaching. [PDF]

PLoS Biol
Voolstra CR.
europepmc   +1 more source