Results 31 to 40 of about 301,259 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identification and Adjustment of Guide Rail Geometric Errors Based on BP Neural Network

Measurement Science Review, 2017
The relative positions between the four slide blocks vary with the movement of the table due to the geometric errors of the guide rail. Consequently, the additional load on the slide blocks is increased.
He Gaiyun, Huang Can, Guo Longzhen, Sun Guangming, Zhang Dawei   +4 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Design, Analysis and Experiment of a Modular Deployable Continuum Robot

Machines
Continuum robots, possessing great flexibility, can accomplish tasks in complex work scenes, regarded as an important direction in robotics. However, the current continuum robots are not satisfying enough in terms of fabrication and maintenance, and ...
Aihu Jia, Xinyu Liu, Yuntao Guan, Yongxi Liu, Qianze Helian, Chenshuo Liu, Zheming Zhuang, Rongjie Kang   +7 more
doaj   +1 more source

Dynamics Modeling and Analysis of an Underwater Glider with Dual-Eccentric Attitude Regulating Mechanism Using Dual Quaternions

Journal of Marine Science and Engineering, 2022
The underwater glider has difficulty accessing the complex and narrow hadal trench for observation, which is affected by its limited regulation capability of pitch angle (−45°~45°).
Peng Wang, Xuehao Wang, Yanhui Wang, Wendong Niu, Shaoqiong Yang, Chao Sun, Chenyi Luo   +6 more
doaj   +1 more source

An Algorithmic Theory of Simplicity in Mechanism Design

A growing body of work in economics and computation focuses on the trade-off between implementability and simplicity in mechanism design. The goal is to develop a theory that not only allows to design an incentive structure easy to grasp for imperfectly rational agents, but also understand the ensuing limitations on the class of mechanisms that enforce
Diodato Ferraioli, Carmine Ventre
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

An sEMG Denoising Method with Improved Threshold Estimation for Rapid Keystroke Tasks

Sensors
Surface electromyography (sEMG) signals are inevitably affected by noise during acquisition, thereby degrading signal quality and analytical reliability.
Pengze Han, Baihui Ding, Penghao Deng, Dengxiong Wu, Huilong Li   +4 more
doaj   +1 more source

Perspectives on Mechanism Design in Economic Theory [PDF]

American Economic Review, 2008
Economics began with Xenophon’s Oeconomicus (c 360 BCE), in which Socrates interviews a model citizen who has two primary concerns. He goes out to his farm in the country to monitor and motivate his workers there. Then he goes back to the city, where his participation in various political institutions is essential for maintaining his rights to own this
openaire   +2 more sources