Tumor necrosis factor is a necroptosis-associated alarmin. [PDF]
Front Immunol, 2022 Necroptosis is a form of regulated cell death that can occur downstream of several immune pathways. While previous studies have shown that dysregulated necroptosis can lead to strong inflammatory responses, little is known about the identity of the ...
Pinci F +5 more
europepmc +3 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Many diseases involve the propagation of misfolded proteins as in prion diseases. Compounds that can inhibit conversion into misfolded conformers exist, but their mechanism of action remains poorly understood. By observing the effects of the
Rafayel M. Petrosyan +4 more
semanticscholar +1 more source
PrP meets alpha‐synuclein: Molecular mechanisms and implications for disease
Journal of Neurochemistry, 2023 The discovery of prions has challenged dogmas and has revolutionized our understanding of protein‐misfolding diseases. The concept of self‐propagation via protein conformational changes, originally discovered for the prion protein (PrP), also applies to ...
Tuane C. R. G. Vieira +3 more
semanticscholar +1 more source
Rabbit PrP Is Partially Resistant to in vitro Aggregation Induced by Different Biological Cofactors
Frontiers in Neuroscience, 2021 Prion diseases have been described in humans and other mammals, including sheep, goats, cattle, and deer. Since mice, hamsters, and cats are susceptible to prion infection, they are often used to study the mechanisms of prion infection and conversion ...
Juliana N. Angelli +5 more
semanticscholar +1 more source
IEEE Transactions on Medical Robotics and Bionics, 2020 Powered knee exoskeletons aim to assist individuals with lower limb impairments by providing power and torque at the joint level. However, if the anatomical and exoskeleton joints are not perfectly aligned, the exoskeleton assistance may result in ...
Sergei V. Sarkisian +3 more
semanticscholar +1 more source
Folia Morphologica, 2022 BACKGROUND Microvesicles (MVs) derived from mesenchymal stem cells exhibited an emerging promising therapy in many animal model diseases. Post-burn scars represent one of the significant challenges in wound healing processes.
R. A. Imam, M. Amer
semanticscholar +1 more source
SYNTHESIS AND ANALYSIS OF A MECHANISM GENERATING THE RATIONAL CIRCULAR CUBIC
Journal of Industrial Design and Engineering Graphics, 2019 Based on the mathematical curve named rational circular cubic [2] and on its animation, it was conceived an original mechanism generating this curve.
Mirela CHERCIU, Iulian POPESCU
doaj +4 more sources
Impact of application of zinc oxide nanoparticles on callus induction, plant regeneration, element content and antioxidant enzyme activity in tomato (Solanum lycopersicum MILL) under salt stress [PDF]
, 2016 The properties of nanomaterials and their potential applications have been given considerable attention by researchers in various fields, especially agricultural biotechnology.
Aldhebiani, AY +3 more
core +2 more sources
Inhibition of the different complement pathways has varying impacts on the serum bactericidal activity and opsonophagocytosis against Haemophilus influenzae type b [PDF]
, 2022 Defense against Haemophilus influenzae type b (Hib) is dependent on antibodies and complement, which mediate both serum bactericidal activity (SBA) and opsonophagocytosis.
Holbro, T. +7 more
core +1 more source
How human papillomavirus replication and immune evasion strategies take advantage of the host DNA damage repair machinery [PDF]
, 2017 The DNA damage response (DDR) is a complex signalling network activated when DNA is altered by intrinsic or extrinsic agents. DDR plays important roles in genome stability and cell cycle regulation, as well as in tumour transformation.
Bordignon, Valentina +8 more
core +2 more sources