Results 1 to 10 of about 11,669,741 (301)

RPA shields inherited DNA lesions for post-mitotic DNA synthesis

Nature Communications, 2021
Single-stranded DNA during DNA replication and repair in S/G2 needs protection by replication protein A (RPA). Here the authors reveal that RPA also shields inherited single-stranded DNA in G1, representing replication remnants from the previous cell ...
Aleksandra Lezaja, Andreas Panagopoulos, Yanlin Wen, Edison Carvalho, Ralph Imhof, Matthias Altmeyer   +5 more
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Dissecting the roles of MBD2 isoforms and domains in regulating NuRD complex function during cellular differentiation

Nature Communications, 2023
The Nucleosome Remodeling and Deacetylation (NuRD) complex is a crucial regulator of cellular differentiation. Two members of the Methyl-CpG-binding domain (MBD) protein family, MBD2 and MBD3, are known to be integral, but mutually exclusive subunits of ...
Nina Schmolka, Ino D. Karemaker, Richard Cardoso da Silva, Davide C. Recchia, Vincent Spegg, Jahnavi Bhaskaran, Michael Teske, Nathalie P. de Wagenaar, Matthias Altmeyer, Tuncay Baubec   +9 more
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Maturity limit of sweet spot area for continental matrix type shale oil: a case study of lower Es3 and upper Es4 sub-members in Dongying Sag, Bohai Bay Basin

Shiyou shiyan dizhi, 2021
The matrix type shale oil will become the main contributer for increasing shale oil reserves and production in China. Maturity is an important factor for the controlling to the distribution of sweet spot area for matrix type shale oil.
Zhiming LI, Zhongliang SUN, Maowen LI, Tingting CAO, Menhui QIAN, Xiaoxiao MA, Peng LIU, Yunjie Bao, Qigui JIANG, Guoliang TAO, Jun ZHANG, Xiaoqing RUI   +11 more
doaj   +1 more source

Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges

Nature Communications, 2022
How rapidly the mutation rate responds evolutionarily to ecological and population-genetic factors over time is unclear. Here, the authors show that the evolution of mutation rates in E. coli proceeds rapidly in response to these factors with substantial
Wen Wei, Wei-Chin Ho, Megan G. Behringer, Samuel F. Miller, George Bcharah, Michael Lynch   +5 more
doaj   +1 more source

Sedimentary environment and organic matter enrichment of the Lower Cambrian Niutitang Formation shale, western Hunan Province, China

Shiyou shiyan dizhi, 2021
The Lower Cambrian Niutitang Formation shale is an extremely crucial marine source rock developed at the mid-upper Yangtze block of China. To clarify the paleoenvironment and conditions which are responsible for organic matter enrichment of the Niutitang
Qingmin ZHU, Longfei LU, Anyang PAN, Jinyu TAO, Jianghui DING, Wangwei LIU, Maowen LI   +6 more
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Microstructure and SEM-Raman study of organic matter pore heterogeneity in shale

Shiyou shiyan dizhi, 2021
The characteristics and influencing factors of pore development in organic matters of shale are of great significance for shale gas exploration and production in China.
Fang BAO, Lingjie YU, Xiaoqing RUI, Qingzhen ZHANG, Ming FAN, Zhongliang MA   +5 more
doaj   +1 more source

Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains

Nature Communications, 2022
Mapping nucleolar-associated domains (NADs) is challenging as the nucleolus is membrane-less. Here the authors adapted the DNA adenine methyltransferase identification (DamID) method by engineering a “nucleolar histone” that can mark genomic contacts ...
Cristiana Bersaglieri, Jelena Kresoja-Rakic, Shivani Gupta, Dominik Bär, Rostyslav Kuzyakiv, Martina Panatta, Raffaella Santoro   +6 more
doaj   +1 more source

Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes

Gut Microbes, 2023
Antidiabetic drug metformin alters the gut microbiome composition in the context of type 2 diabetes and other diseases; however, its effects have been mainly studied using fecal samples, which offer limited information about the intestinal site-specific ...
Laila Silamiķele, Rihards Saksis, Ivars Silamiķelis, Patrīcija Paulīne Kotoviča, Monta Brīvība, Ineta Kalniņa, Zane Kalniņa, Dāvids Fridmanis, Jānis Kloviņš   +8 more
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Experimental development and application of source rock thermal simulation for hydrocarbon generation and expulsion

Shiyou shiyan dizhi, 2021
Simulation experiment was one of the most valuable methods for the study of hydrocarbon generation, expulsion and retention in source rocks. It was summarized in this paper that the progressing status and development significations of thermal simulation ...
Chuan HE, Lunju ZHENG, Qiang WANG, Zhongliang MA, Jianfei MA   +4 more
doaj   +1 more source

Reconstruction of paleo-temperature and pressure of oil reservoirs based on PVTx simulation: problems, strategies and case studies

Shiyou shiyan dizhi, 2021
The PVTx simulation of fluid inclusions is a valuable method for the reconstruction of paleo-temperature and pressure of oil reservoir. Since the accurate composition of oil-bearing inclusion is very difficult to be obtained and the composition may be ...
Binbin XI, Hong JIANG, Jin XU, Qianglu CHEN, Donghua YOU   +4 more
doaj   +1 more source