Results 81 to 90 of about 11,669,741 (301)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
, 2015 Consider an exchange mechanism which accepts diversified offers of various commodities and redistributes everything it receives. We impose certain conditions of fairness and convenience on such a mechanism and show that it admits unique prices, which ...
Dubey, Pradeep +2 more
core
Journal of Biomechanics, 2014 Plaque mechanics, the deformation and corresponding stress distribution, play an important role in various aspects of atherosclerotic disease. This special issue is composed of reviews and original research articles of the state-of-the-art, focusing on different topics that relate to plaque mechanics.
FJH Gijsen, MIGLIAVACCA, FRANCESCO
openaire +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Petroleum Science, 2018 For a typical marine shale reservoir in the Jiaoshiba area, Sichuan Basin of China, P-impedance is sensitive for identifying lithology but not suitable for indicating good shale reservoirs.
Yuan-Yin Zhang +5 more
doaj +1 more source
Author Correction: Small-wedge synchrotron and serial XFEL datasets for Cysteinyl leukotriene GPCRs
Scientific Data, 2020 A Correction to this paper has been published: https://doi.org/10.1038/s41597-020-00759 ...
Egor Marin +12 more
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Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency
EMBO ReportsPluripotency is established in E4.5 preimplantation epiblast. Embryonic stem cells (ESCs) represent the immortalization of pluripotency, however, their gene expression signature only partially resembles that of developmental ground-state. Induced PRAMEL7
Meneka Rupasinghe +7 more
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The epigenetic circle: feedback loops in the maintenance of cellular memory
Epigenetics & ChromatinThe memory of gene expression states, active or repressive, is a fundamental biological concept as it controls cell fate in development, immunity and abiotic stress responses.
Marko Tomljanović +3 more
doaj +1 more source