Results 81 to 90 of about 169,186,284 (259)
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Mechanisms and Initiatives of the Public Administration Reform in the Republic of Serbia
Iustinianus Primus Law Review, 2013 Throughout the last decade, reforming the public sectors has proven to be a demanding endeavor, both for the developed and economically strong governments, as well as for the states that are in stadium of development.
Aleksandra Stanojevic
doaj
Соціально-економічні відносини в цифровому суспільствіThe article is devoted to a comprehensive study of institutional and legal mechanisms for ensuring legality and discipline in public administration bodies.
Artem Chubai
doaj +1 more source
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Achieving equality in progressive contexts: queer(y)ing public administration [PDF]
, 2020 In many countries, including the UK, the majority of legal impediments to equality for LGBT+ people have been removed, and legislation actively promotes equality for LGBT+ people.
Poyner, Chris, Matthews, Peter
core
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
, 2017 In this study, the authors seek to identify mechanisms of publicness present within mental health treatment facilities and, subsequently, explore the constraints these mechanisms impose on facilities’ capacities to achieve public outcomes.
Farnworth, Morgan D. +2 more
core +1 more source
Brazilian Journal of Empirical Legal Studies, 2014 This paper aims to analyze part of the empirical data generated from a research performed for the Projeto Pensando o Direito (Project Thinking the Law) on the mechanisms for modernization of public management, supported by United Nations Development ...
Irene Patrícia Nohara
doaj +1 more source
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source