Results 31 to 40 of about 16,835 (218)

Mechanistic Modeling of Architectural Vulnerability Factor [PDF]

ACM Transactions on Computer Systems, 2015
Reliability to soft errors is a significant design challenge in modern microprocessors owing to an exponential increase in the number of transistors on chip and the reduction in operating voltages with each process generation. Architectural Vulnerability Factor (AVF) modeling using microarchitectural simulators enables architects to make informed ...
Arun Arvind Nair, Stijn Eyerman, Jian Chen, Lizy Kurian John, Lieven Eeckhout   +4 more
openaire   +3 more sources

Mechanistic modeling of viral particle production

Biotechnology and Bioengineering, 2022
AbstractViral systems such as wild‐type viruses, viral vectors, and virus‐like particles are essential components of modern biotechnology and medicine. Despite their importance, the commercial‐scale production of viral systems remains highly inefficient for multiple reasons.
Christopher T. Canova, Pavan K. Inguva, Richard Braatz   +2 more
openaire   +3 more sources

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Addressing the long-standing limitations of double exponential and non-rectangular hyperbolic models in quantifying light-response of electron transport rates in different photosynthetic organisms under various conditions

Frontiers in Plant Science
The models used to describe the light response of electron transport rate in photosynthesis play a crucial role in determining two key parameters i.e., the maximum electron transport rate (Jmax) and the saturation light intensity (Isat). However, not all
Zi-Piao Ye, Ting An, Govindjee Govindjee, Piotr Robakowski, Alexandrina Stirbet, Xiao-Long Yang, Xing-Yu Hao, Hua-Jing Kang, Fu-Biao Wang   +8 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Investigation on Rod Bundle CHF Mechanistic Model for DNB and DO Prediction Under Wide Parameter Range

Frontiers in Energy Research, 2021
For a water cooled reactor, the key thermal-hydraulic parameters span a wide range corresponding to different CHF regimes. Under accident conditions, due to the flow regime transition and interchannel mixing effect, the corresponding CHF can transition ...
Wei Liu, Shinian Peng, Guangming Jiang, Yu Liu   +3 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

How to Model Mechanistic Hierarchies [PDF]

Philosophy of Science, 2016
Mechanisms are usually viewed as hierarchical, with lower levels of a mechanism influencing, and decomposing, its higher-level behavior. To draw quantitative predictions from a model of a mechanism, the model must capture this hierarchical aspect. Recursive Bayesian networks (RBNs) were put forward by Lorenzo Casini et al.
openaire   +3 more sources

Mechanistic models in computational social science [PDF]

Frontiers in Physics, 2015
Quantitative social science is not only about regression analysis or, in general, data inference. Computer simulations of social mechanisms have a 60-year long history. They have been used for many different purposes -- to test scenarios, test the consistency of descriptive theories (proof-of-concept models), explore emergent phenomena, forecast, etc ...
Holme, Petter, Liljeros, Fredrik
openaire   +3 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source