Results 81 to 90 of about 16,835 (218)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Mechanistic Modeling in Biosystem Engineering: A Review on Mechanistic Models of Calcium Metabolism

Food Engineering Progress, 2013
Calcium is an essential nutrient generally obtained from dietary foods. However, its metabolism is a complex biological network requiring an effective analytical tool. In this review, a few notable calcium mechanistic models are assessed, emphasizing the power of mechanistic modeling in analyzing biological systems because no publication has reviewed
Wang-Hee Lee, Byoung-Kwan Cho
openaire   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Understanding mechanistic relationships between IgG titers and Fc effector functions: a computational framework to assess polyfunctionality

Frontiers in Immunology
IntroductionRecent vaccine and infectious disease studies have highlighted the importance of antibodies that activate cellular Fc functions, including antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotoxicity (ADCC ...
Suzanne K. Shoffner-Beck, Robert M. Theisen, Kade E. Wong, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayaphan, Stephen Kent, Stephen Kent, Amy W. Chung, Kelly B. Arnold   +9 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Towards Zero-Defect Manufacturing Based on Artificial Intelligence through the Correlation of Forces in 5-Axis Milling Process

Machines
Zero-Defect Manufacturing (ZDM) is a promising strategy for reducing errors in industrial processes, aligned with Industry 4.0 and digitalization, aiming to carry out processes correctly the first time.
Itxaso Cascón-Morán, Meritxell Gómez, David Fernández, Alain Gil Del Val, Nerea Alberdi, Haizea González   +5 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Combining eDNA Metabarcoding, Hydrology‐Based Modeling and Camera Trap Datasets to Assess the Potential of River eDNA in Monitoring Terrestrial Mammals

Environmental DNA
Global efforts aimed at safeguarding and restoring biodiversity require methods to monitor progress towards conservation objectives. Such methods should provide a systematic and robust assessment of biodiversity for the lowest cost.
Monika Goralczyk, Arnaud Lyet, Robin Naidoo, Cole Burton, Loïc Pellissier, Luca Carraro   +5 more
doaj   +1 more source