Results 121 to 130 of about 36,809 (300)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu +21 more
wiley +1 more source
Kajiado County Agricultural Mechanization Services Policy, 2019
, 2019 Agricultural sector is important in contributing to food security, production of agro-based raw materials, employment creation, income generation and earning of foreign exchange.
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Design and simulation of key components for mechanical transplanting of large pineapple seedlings
Frontiers in Plant SciencePineapple is an important characteristic crop in tropical and subtropical regions of China. In production, the proportion of labor costs is high and the level of mechanization is low, which hinders the full play of the industrial potential.
Junwang Guo +9 more
doaj +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Agricultural mechanization policies in the Philippines [PDF]
, 2015 This paper presents the past policies and policy directions of the Philippines in relation to agricultural mechanization. It also provides the activities of the Agricultural Mechanization Development Program (AMDP), Institute of Agricultural Engineering (
UN.ESCAP +3 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is a common non‐motor symptom in Multiple Sclerosis (MS), negatively affecting autonomy and Quality of Life (QoL). Innovative rehabilitation strategies, such as semi‐immersive virtual reality (VR) and computerized cognitive training (CCT), may offer advantages over traditional cognitive rehabilitation (TCR ...
Maria Grazia Maggio +8 more
wiley +1 more source
Efficiency Effects Zimbabwe’s Agricultural Mechanization and Fast Track Land Reform Programme: A Stochastic Frontier Approach [PDF]
A development goal pursued by the Zimbabwean government even before the much-maligned fast track land reform programme (FTLRP) was expansion of agricultural production through agricultural mechanization. This goal has been pursued through the acquisition
Chisango, Future Fortune T. +1 more
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Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng +4 more
wiley +1 more source