Results 41 to 50 of about 15,365 (228)

Advancements in Glioblastoma Multiforme Treatment: A Comprehensive Systematic Review and Meta‐Analysis

Brain and Behavior, Volume 16, Issue 5, May 2026.
This study is a systematic review and meta‐analysis comparing bevacizumab‐, temozolomide‐, and lomustine‐based treatments for recurrent glioblastoma. The findings suggest that monotherapy, particularly bevacizumab, may provide better clinical outcomes with fewer adverse events than combination regimens. ABSTRACT Background Glioblastoma multiforme (GBM)
Kayode Agboola, Fatemeh Khafaji, Bipin Chaurasia, Kashif Qureshi, Kivanc Yangi, Vishal Chavda, Naci Balak   +6 more
wiley   +1 more source

Adults With Acid Sphingomyelinase Deficiency Have Sustained Improvements in Clinical Outcomes With up to 5 Years of Olipudase Alfa Enzyme Replacement Therapy: ASCEND Trial Final Results

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Acid sphingomyelinase deficiency (ASMD) is a rare debilitating lysosomal storage disease resulting in multisystemic disease manifestations, significant disease burden, and early mortality for some individuals. Enzyme replacement therapy (ERT) with olipudase alfa (Xenpozyme) is the first disease‐specific treatment indicated for noncentral ...
Melissa P. Wasserstein, Carla E. Hollak, Antonio Barbato, Renata C. Gallagher, Roberto Giugliani, Norberto Bernardo Guelbert, Julia B. Hennermann, Takayuki Ikezoe, Robin Lachmann, Olivier Lidove, Paulina Mabe, Eugen Mengel, Maurizio Scarpa, Ebubekir Senates, Michel Tchan, Beth L. Thurberg, Jesus Villarrubia, Nicole M. Armstrong, Shashi Bhushan, Yong Kim, Monica Kumar   +20 more
wiley   +1 more source

İslam Medeniyetinde Pozitif İlimlerin Gelişimi Üzerine Bir Değerlendirme

Atebe, 2022
Müslümanlar Kur’ân’ın ilk emri olan okumayı sadece yüzeysel bir okuma değil varlığın özüne inmek ve dünyayı anlamak olarak değerlendirmişlerdir. Bu doğrultuda ilk zamanlardan itibaren etraflarında gelişen tüm olayları ibret nazarıyla incelemişler ve ilmî
Yavuz Selim Göl
doaj   +1 more source

Diversity Combining for RF Energy Harvesting [PDF]

, 2017
RF energy harvesting (RFEH) is a promising technology for energy requirements of wireless communication nodes. However, providing sufficient amount of energy to ensure self-sufficient devices based on RFEH may be challenging.
Altinel, Dogay, Kurt, Gunes Karabulut
core   +1 more source

Review of patient‐reported outcomes in EMPOWER‐Lung 1 in patients with advanced non‐small cell lung cancer treated with cemiplimab versus chemotherapy

Cancer, Volume 132, Issue 6, 15 March 2026.
Abstract Background Patient‐reported outcomes (PROs) for cemiplimab monotherapy versus chemotherapy from the EMPOWER‐Lung 1 phase 3 clinical trial (ClinicalTrials.gov identifier NCT03088540) in patients who had advanced non‐small cell lung cancer with programmed cell death‐ligand 1 expression ≥50% were previously reported.
David R. Gandara, Mahmut Gümüş, Saadettin Kilickap, Ahmet Sezer, Igor Bondarenko, Mustafa Özgüroğlu, Miranda Gogishvili, Eric Yan, Xue Jia, Eric Kim, Frank Seebach, Ruben G. W. Quek   +11 more
wiley   +1 more source

Türkiye Selçuklu Medreselerinde Eğitim ve Yaşamla İlgili Temel Birimler

Ortaçağ Araştırmaları Dergisi, 2021
Malazgirt savaşından sonraki süreçte, Anadolu’yu hızla vatanlaştıran Selçuklular, aynı zamanda burada çok ileri seviyede bir medeniyet de oluşturmuşlardır.
İbrahim Balık
doaj   +1 more source

A Comprehensive Overview of the Clinical, Electrophysiological, and Neuroimaging Features of BPAN: Insights From a New Case Series

Annals of Clinical and Translational Neurology, Volume 13, Issue 3, Page 453-465, March 2026.
ABSTRACT Background Neurodegeneration with brain iron accumulation (NBIA) comprises a genetically and clinically heterogeneous group of rare neurological disorders characterized particularly by iron accumulation in the basal ganglia. To date, 15 genes have been associated with NBIA.
Seda Susgun, Ozgu Kizek, Sibel Aylin Ugur Iseri, Ibrahim Kamaci, Ayse Deniz Elmali, Pinar Iscen, Berfin Gulkaya Guzel, Gul Yalcin Cakmakli, Bulent Elibol, Berril Donmez, Raif Cakmur, Pinar Topaloglu, Turkish NBIA Study Group, Abdullah Acar, Ahmet Acarer, Arzu Karabay, Asuman Ali, Ayla Barlas, Aysegul Gunduz, Banu Ozen Barut, Baris Baslo, Bilge Kocer, Bilgehan Mus, Birsen Karaman, Burcu Gokce Cokal, Cem Ismail Kucukali, Cenk Akbostanci, Ceyhun Sayman, Cagla Turan, Dilek Ince Gunal, Ebru Bilge Dirik, Ebru Erzurumluoglu, Elif Kocasoy Orhan, Enes Demiryurek, Emrah Yucesan, Ercan Kose, Erdem Tuzun, Esen Saka Topcuoglu, Esra Okuyucu, Fatma Betul Ozdilek, Feriha Ozer, Gencer Genc, Gozde Unal, Gulay Kenangil, Gullu Tarhan, Gunes Kiziltan, Halil Onder, Hamit Genc, Hasmet Hanagasi, Hatice Yuksel, Hulya Apaydin, Koray Kirimtay, Mehmet Guney Senol, Melisa Kilic, Meltem Demirkiran, Mert Karaca, Miray Erdem, Muhammet Bilgehan Mus, Murat Gultekin, Nalan Capan, Nazan Karagoz Sakalli, Nazli Basak, Nihan Hande Akcakaya, Ozan Ezer, Ozge Uygun, Ozge Yilmaz Kuspeci, Ozgur Oztop Cakmak, Pervin Iseri, Petek Ballar Kirmizibayrak, Pinar Elkoca, Recep Alp, Remzi Yigiter, Rezzak Yilmaz, Sadika Ozdemir, Selda Keskin, Selen Ilhan Alp, Selen Soylu, Serdar Ceylaner, Serhat Ozkan, Sevda Erer Ozbek, Sevgin Gundogan, Sevil Yasufli, Sezin Alpaydin Baslo, Sibel Ertan, Sultan Cagirici, Seyma Aykac, Vuslat Yilmaz, Yaprak Secil, Yasar Kutukcu, Yeliz Ciftci, Yesim Sucullu Karadag, Yildiz Değirmenci, Zeliha Matur, Nerses Bebek, Murat Emre, Zuhal Yapici   +95 more
wiley   +1 more source

Increased expression of YAP1 in prostate cancer correlates with extraprostatic extension. [PDF]

, 2017
Objective:Yes associated protein 1 (YAP1) is a member of the Hippo pathway, acting as a transcriptional coactivator. To elucidate the role of YAP1 and phosphorylated (p)YAP1 in prostate cancer (PCa) tumorigenesis, we investigated their expression in ...
Collak, Filiz Kisaayak, Demir, Ummuhan, Kurum, Esra, Ozkanli, Seyma, Zerk, Pinar Engin   +4 more
core  

Tofacitinib for the Treatment of Juvenile Idiopathic Arthritis: Patient‐Reported Outcomes in a Phase 3, Randomized, Double‐Blind, Placebo‐Controlled Withdrawal Trial

Arthritis &Rheumatology, Volume 78, Issue 3, Page 752-762, March 2026.
Objective Juvenile idiopathic arthritis (JIA) is associated with impaired overall health‐related quality of life (HRQoL). We evaluated the impact of tofacitinib on patient‐reported outcomes (PROs) in patients with JIA. Methods This was a post hoc analysis of a phase 3, randomized, double‐blind, placebo‐controlled withdrawal trial (NCT02592434) in ...
Hermine I. Brunner, Ekaterina Alexeeva, Marcia Bandeira, Ruy Carrasco, Jeffrey Chaitow, Peter Chiraseveenuprapund, Tracy V. Ting, Muferet Erguven, Beth Gottlieb, Sheila Knupp Oliveira, Pooja N. Patel, Seza Ozen, Claudia Saad Magalhaes, Inmaculada Calvo Penadés, David Gruben, Rebecca Germino, Holly B. Posner, Lori Stockert, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto, for the Paediatric Rheumatology International Trials Organisation (PRINTO) and Pediatric Rheumatology Collaborative Study Group (PRCSG)   +21 more
wiley   +1 more source

MEDENİYET KAVRAMINI AÇIKLAMAK İÇİN BİR YAKLAŞIM

Felsefe Dünyası, 2019
Medeniyet Kavramını Açıklamak için Bir YaklaşımBu çalışmada medeniyet kavramının anlamını açıklığa ve seçikliğe kavşturmak için bir yaklaşım önerilmiştir. Medeniyet ve kültür kavramlarının tanımlarında, tutarsızlıklar, belirsizlikler sözkonusudur. Kültür,
Durmuş Günay
doaj