Results 31 to 40 of about 74,126 (310)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Agenda setting in the world of online news: New questions for new environment [PDF]

CM. Communication and Media, 2016
This paper explores whether agenda setting theory is a fruitful approach to understand online news communication. To answer this question, the distinction between vertical and horizontal media is used and applied to online communication in order to ...
Ninković-Slavnić Danka
doaj  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

The Image of Healthcare and Healthcare Professionals in the Russian Television Media Agenda in 2019–2021 / Образ медицины и медиков в российской телевизионной медиаповестке в период 2019–2021 гг.

Наука телевидения, 2022
In this article, we analyze the image of healthcare and health professionals in the Russian television media agenda before and during the COVID-19 pandemic and determine the frequency and content of health-related news reports on federal and regional ...
NOR-AREVYAN OXANA A. / НОР-АРЕВЯН О.А., MOSIENKO OLGA S. / МОСИЕНКО О.С., CHEREVKOVA ALENA I. / ЧЕРЕВКОВА А.И.   +2 more
doaj   +1 more source

PERAN AGENDA SETTING MEDIA MASSA DALAM KEBIJAKAN PENETAPAN HARGA ECERAN TERTINGGI (HET) BERAS OLEH PEMERINTAH [PDF]

, 2018
Dalam kehidupan sehari â hari media massa menyajikan beragam informasi, berita, isu, peristiwa yang terjadi di masyarakat. Perkembangan teknologi yang memudahkan masyarakat menerima sebuah informasi dengan cepat menjadikan masyarakat semakin terbuka ...
Agustina Irwansyah, Tri
core  

Media discourse on jihadist terrorism in Europe

, 2014
This article analyzes the manner in which European print media discuss jihadist terrorism in Europe. It presents key results from a qualitative analysis of media discourse following three selected attacks in seven European countries in 2010: the attack ...
Reinke de Buitrago, Sybille
core   +1 more source

The interplay between parties and media in putting EU issues on the agenda [PDF]

, 2017
We investigate the interplay between party communication and media coverage in putting EU issues on the agenda during the 2014 European Parliamentary election campaigns in Austria, Germany and the United Kingdom.
Maier, Michaela, Adam, Silke, Patrick Bacherle, Silke Adam, Leidecker-Sandmann, Melanie, Bacherle, Patrick, Melanie Leidecker-Sandmann, Michaela Maier   +7 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source