Results 161 to 170 of about 143,839 (291)
Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐randomness hardware platform is demonstrated by integrating PUF and TRNG functionalities into mixed‐ZGO nanoclusters. By leveraging spatial and temporal stochasticity, the mixed‐ZGO NCs device enables both unique identification and random signal generation.
Seungme Kang +6 more
wiley +1 more source
Advanced Science, EarlyView.Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan +12 more
wiley +1 more source
The New Paradigms: Artificial Intelligence, Metamedia, and Educational Horizons
Проблеми на постмодерносттаThe first issue of the 2025 year includes articles by scholars from Bulgaria, Greece, Azerbaijan, Kosovo, and Kenya. As we stated in the previous issue, all roads lead to AI.
Stella Angova, Ivan Valchanov
doaj
Advanced Science, EarlyView.A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan +5 more
wiley +1 more source
ACMA communications report 2013-14
, 2014 Executive summary Key trends Mobile services are now at saturation levels with 2013–14 seeing the first, albeit small, decline in the number of mobile services in operation to 31.01 million mobile services—a 0.3 per cent decline on the previous year ...
Australian Communications and Media Authority
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In Vivo CRISPR Screen Identifies RPS19 as an Immunotherapy Target in Hepatocellular Carcinoma
Advanced Science, EarlyView.By employing in vivo CRISPR functional screening, we identify ribosomal protein RPS19 as a pivotal mediator driving immune evasion in hepatocellular carcinoma, wherein tumor‑released RPS19 binds C5aR1 on tumor‑associated macrophages to initiate downstream immunosuppressive signaling; SP94‑peptide‑modified SNPSS nanoparticles deliver Cas9/sgRPS19 ...
Lei He +20 more
wiley +1 more source
Social Media and the New Organization of Government Communications
, 2016 A. Meijer, R. Torenvlied
semanticscholar +1 more source
Rethinking European Media and Communications Policy
Front -- Table of Contents -- Foreword -- The Converging Media and Communications Environment -- Information, Telecommunication Technologies and Media Convergence Challenges -- Social Computing -- The New Audiovisual Media Services Directive ...
Donders, Karen. +3 more
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