Results 51 to 60 of about 84,625 (296)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Pengaruh Ad Relevance, Ad Saliance, Ad Engagement, Perceived Goal Impediment terhadap Advertising Avoidance dengan Motivasi sebagai Variabel Moderasi

Jurnal Manajemen Teori dan Terapan, 2020
The increase in internet users has made marketers move to online media. The existence of adertisements in online media has the potential to disturb consumers and cause them to avoid advertising.
Mentari Septynaputri Widodo, Masmira Kurniawati   +1 more
doaj   +1 more source

Media Exposure, Cancer Beliefs, and Cancer-Related Information-Seeking or Avoidance Behavior Patterns in China [PDF]

, 2021
Rui He, Yungeng Li
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Social media addiction in high school students: examining its relationship with school burnout, fear of negative evaluation and cognitive avoidance

Multidisciplinary Journal for Education, Social and Technological Sciences
Today, adolescents’ use of social media increasingly common, even including during school hours and class sessions. To address this issue and design effective interventions, it is essential to understand the psychological factors contributing to the ...
Gizem Karaoğlan Yılmaz, Ramazan Yılmaz, Nurgün Gençel   +2 more
doaj   +1 more source

Conspiracy Theories and Institutional Trust: Examining the Role of Uncertainty Avoidance and Active Social Media Use [PDF]

, 2021
Silvia Mari, Homero Gil de Zúñiga, Ahmet Süerdem, Katja Hanke, Gary Brown, Roosevelt Vilar, Diana Boer, Michał Bilewicz   +7 more
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Selective and consistent news avoidance in Aotearoa New Zealand: motivations and demographic influences

Kōtuitui
This study explores selective and consistent news avoidance in Aotearoa New Zealand. Existing research suggests that selective news avoidance rates are high in Aotearoa New Zealand (Myllylahti M, Treadwell G. 2023.
Alex Beattie, John Kerr, Richard Arnold
doaj   +1 more source

Studi Korelasi Pesan Penagihan Koleksi Perpustakaan melalui Whatsapp dengan Sikap Pemustaka Terhadap Sanksi Administratif

Khizanah al-Hikmah, 2018
Tujuan penelitian ini adalah untuk mengetahui hubungan pesan penagihan koleksi melalui media sosial dengan sikap pemustaka terhadap sanksi administratif perpustakaan, dengan menguji hubungan intensitas, isi pesan, dan daya tarik pesan dengan penghindaran
Aulia Asmayanti, Prijana Prijana, Andri Yanto   +2 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source