Results 101 to 110 of about 6,011,320 (352)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Identification of Design and Development Needs for Preschool-aged Children's Educational Bags [PDF]

, 2017
Bags for students, especially for preschool-aged children have an important role, namely as learning media in the field of education. Attractive and innovative bag designs are highly required to make acceptable and favorable bags for children.
Cahyadi, D. (Dwi), Fibrianie, E. (Etwin)
core  

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Design of Mathematics Learning Media based on Discovery Learning to Improve Problem Solving Ability

Indonesian Journal on Learning and Advanced Education (IJOLAE), 2019
Problem-solving is one of the 21st century skills and is included in the 2013 curriculum. Students with low problem-solving abilities will have difficulty completing math problems that require high-level thinking.
Epa Wira Darmawan, Suparman Suparman
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Making Meaning of Media Development Today

International Journal of Communication, 2019
This article aims to fill a gap in the academic literature on how employees at a media development intermediary construct meaning of their work. Based on in-depth interviews with 18 employees of Internews, this research shows that employees believe the ...
Margaretha Geertsema-Sligh
doaj   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

KUALITAS BONBON BOND SEBAGAI MEDIA PEMBELAJARAN PADA TOPIK IKATAN KIMIA [THE QUALITY OF BONBON BOND AS A LEARNING MEDIA FOR CHEMICAL BONDING TOPICS]

Polyglot: Jurnal Ilmiah, 2018
This study aims to determine the quality of the Android-based courseware program named Bonbon Bond for chemical bonding topics. This research is one of a sequence in Research and Development work. The subject of this study was senior high school students
Indah Sari, Imas Eva Wijayanti, Nidaurrohmah Nidaurrohmah   +2 more
doaj   +1 more source

No. 26: Social Media, The Internet and Diasporas for Development [PDF]

, 2011
The recent focus on diasporas by policy-makers researchers has highlighted the rich potential of migrants as a force for shaping development activities in their countries of origin.
Caesar, Mary, Chikanda, Abel, Crush, Jonathan, Eberhardt, Cassandra, Hill, Ashley, Pendleton, Wade   +5 more
core   +1 more source