Results 131 to 140 of about 22,247,482 (397)
FEBS Letters, EarlyView.Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican +7 more
wiley +1 more source
JupitekMathematics picture story books are learning media that can help students learn mathematics content both independently or through active interaction in the classroom.
Marlin Blandy Mananggel +2 more
doaj +1 more source
Forecasting media market development
, 2011 This paper gives an outlook about the development of the Swiss media industry in the coming years. The outlook is based on two cornerstones: the economic development as the basis of a media system within a market economy and the social function of media within modern democracies.
von Rimscha, Björn +2 more
openaire +2 more sources
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Jurnal Pendidikan Dasar Nusantara, 2018 Background of this research is that tematik teaching media are limited. It is influence the students interesting in learning process are not optimal.
Dewi Saraswati, Arfilia Wijayanti
doaj +1 more source
Development Impact of Social Media
, 2015 This paper assesses the role of social media in social and economic development. The web and in particular, social media such as social network sites (e.g. Facebook) and microblogs (e.g. Twitter), allows ordinary citizens to connect with one another and share information via computer-mediated networks.
Ackland, Robert, Tanaka, Kyosuke
openaire +2 more sources
Media use and brain development during adolescence
Nature Communications, 2018 The current generation of adolescents grows up in a media-saturated world. However, it is unclear how media influences the maturational trajectories of brain regions involved in social interactions.
E. Crone, E. Konijn
semanticscholar +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
From the Field: Windows of Opportunity – The Transformation of State Media to Public Service Media in Kyrgyzstan, Mongolia, Moldova and Serbia [PDF]
Global Media Journal: German Edition, 2015 The transformation of state media to public service media (PSM) is one of the most ambitious endeavors in the field of media development. Not many efforts to free the national media from government control have succeeded in the past decades.
Jan Lublinski +5 more
doaj