Results 171 to 180 of about 4,306,154 (354)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Manipulating truth in media discourse

open access: yesJournal of Contemporary Philology, 2019
Тhis paper aims to investigate the language journalists use to present news from a certain perspective and thus create public opinion. More precisely, it offers a critical discourse analysis of Macedonian and American journalistic texts reporting on one ...
Zorica Trajkova
doaj  

When Anonymous Controlling Professional Media: A Marginal Voice in Press Freedom Country [PDF]

open access: yes, 2014
The emergence of citizen journalism get a skeptical response from professional journalists based on several reasons such as un-institutional, subjective and nonprofessional (O¨rnebring, 2013; Allan, 2009; Moyo, 2009).
Nurul, Hasfi
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

The Common Disaster and the Unexpected Education: Delta Flight 1141 and the Discourse of Aviation Safety [PDF]

open access: yes, 1996
News coverage of transportation disasters, such as the crash of Delia Flight 1141, reveal the disaster behavior of passengers, flight personnel and rescue workers.
Garner, Ana C.
core   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

Critical discourse analysis on Mandalika and Likupang social media

open access: yesDiglosia
The implications of the pandemic have drastically decreased tourism occupancy in Indonesia, prompting the president to develop super priority destinations, such as Mandalika and Likupang, to restore tourism occupancy. Focusing on Mandalika and Likupang,
Eka Dyah Puspita Sari   +3 more
doaj   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

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