Results 91 to 100 of about 1,722,858 (295)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Flipbook on Indonesian cultural diversity to enhance learning outcomes for fourth graders

Research and Development in Education
Researchers have conducted observations at SDN Denanyar 3 Sragen and obtained problematic results, namely limited learning media and low student learning outcomes in Social Sciences subjects.
Hilda Kusumaningtyas, Ali Sunarso
doaj   +1 more source

Ranu Pani Resort Orchid Diversity Atlas

Jurnal Pendidikan Sains, 2019
: This research aims to determine the validity of orchid diversity atlas in the Plant Diversity course for Biology Education students. This research was a development research that referred to ADDIE development model which was limited to the stage of ...
Novita Yanuartanti, Susriyati Mahanal, Murni Saptasari   +2 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

DIVERSITY EFFORTS IN INDEPENDENT SCHOOLS [PDF]

, 2001
When it comes to diversity, many high-end institutions--including those in education, politics, and media--have been slow to change and reluctant to promote people who do not fit a certain profile.
Brosnan, Michael
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Presseförderung als Mittel gegen Medienkonzentration und für die publizistische Vielfalt? Quasi-experimentelle Untersuchung der Schweiz im Vergleich zu Belgien, Österreich, Irland sowie Deutschland

Studies in Communication Sciences, 2018
Mass media play a certain role for society in democratic systems. Communication research faces this role by analyzing media performance. Well performing media provide the society with a diversity of topics, opinions, and sources.
Steffen Kolb, Mathias Oertel
doaj   +1 more source

Media of the people: broadcasting community media in Australia [PDF]

Provides an overview of Australia\u27s community media sector, looking at its origins and composition and the problems it faces in light of the tasks it performs and the lack of resources available to it to deliver a media which is ‘of the people’ in ...
Rhonda Jolly
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Editorial: Strategic narratives in political and crisis communication: Responses to COVID-19

Frontiers in Communication, 2022
Victoria Ann Newsom, Lara Lengel, Anca Birzescu, Christian Vukasovich   +3 more
doaj   +1 more source