Results 71 to 80 of about 1,722,858 (295)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Affect, credibility, and solidarity: strategic narratives of NGOs’ relief and advocacy efforts for Gaza

Online Media and Global Communication
This study explores an under-researched area: NGOs’ efforts to provide humanitarian relief during armed conflict. It examines visuals posted on the Instagram accounts of 14 NGOs whose mission is to support civilians impacted by the Gaza humanitarian ...
Ziberi Linda, Lengel Lara, Limani Artan, Newsom Victoria A.   +3 more
doaj   +1 more source

Work Force Diversity [PDF]

, 2015
Diversity management is process of creating and maintaining the workforce which is embalmed in the nutshell of sex, caste, religion, gender race etc. Diversity is today the main word behind the globalized era of creating a diversify culture blend in with
Ali, M. (Mujjamil), David, S. (Shine), Jadoun, D. S. (Devashish), pejwal, M. S. (Mohit), Yadav, H. (Himanshu)   +4 more
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Public Service Media in the Digital Age| Diversity by Choice: Applying a Social Cognitive Perspective to the Role of Public Service Media in the Digital Age

International Journal of Communication, 2015
Hopes for a new abundance of diverse media content have long been tied to the rise of the Internet. Ensuring diversity remains a fundamental objective of media policy. However, media policy is still largely focused on public service media.
Christian Pieter Hoffman, Christoph Lutz, Miriam Meckel, Giulia Ranzini   +3 more
doaj   +2 more sources

Public Service Media and Diversity in the Digital Media Landscape: Opportunities and Limitations for Social Justice

Studies in Social Justice
This essay reviews the place and role of Public Service Media (PSM) in promoting social justice in the changing digital media landscape through the ethos of diversity.
Aya Yadlin, Oranit Klein-Shagrir
doaj   +1 more source

Culture Media and Individual Hosts Affect the Recovery of Culturable Bacterial Diversity from Amphibian Skin

Frontiers in Microbiology, 2017
One current challenge in microbial ecology is elucidating the functional roles of the large diversity of free-living and host-associated bacteria identified by culture-independent molecular methods.
Daniel Medina, Jenifer B. Walke, Zachary Gajewski, Matthew H. Becker, Meredith C. Swartwout, Lisa K. Belden   +5 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

MEDIA SIBER, APARAT, DAN PEMBERITAAN KEBERAGAMAN

Jurnal Aspikom, 2019
The up and down of relations between the government and the media have been the topic of various studies for decades. Historically, relations between the two parties were characterized by unequal power relations.
Riris Loisa, Eko Harry Susanto, Ahmad Junaidi, Felicia Loekman   +3 more
doaj   +1 more source