Results 121 to 130 of about 1,977,651 (265)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Understanding news-related user comments and their effects: a systematic review

open access: yesFrontiers in Communication
There has been growing interest in research on news-related user comments. Here we conduct the first systematic review of this literature—quantitatively and qualitatively (248 studies)—that covers the entire communication process (content analyses ...
Emily Kubin   +6 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Headlines and hashtags herald new ‘damaging effects’: Media and Australia’s declining PISA performance

open access: yes, 2018
This chapter provides a comparative analysis of print and social media representations of Australia’s changing performance on the OECD’s triennial Program for International Student Assessment (PISA), focusing on the 2016 dissemination of the 2015 results.
Bob Lingard   +3 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Social media and online self-presentation: Effects on how we see ourselves and our bodies [PDF]

open access: yes, 2014
Social media are becoming more and more popular. Many adolescents and adults present themselves online through a social network site or dating profile. Such widespread engagement in self-presentation on social media may have implications for how we see ...
de Vries, D.A.
core  

The contribution of media consumption to civic participation

open access: yes, 2008
A national UK survey (N=1017) examined the contribution of media consumption to explaining three indicators of civic participation – likelihood of voting, interest in politics, and actions taken in response to a public issue of concern to the respondent.
Markham, Tim   +2 more
core   +1 more source

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