Results 101 to 110 of about 1,079,714 (313)

Disruption of the Broadcast [PDF]

open access: yes, 2017
“The role of the media … forces us to ask what kind of a world and what kind of a society we want to live in, and in particular, in what sense of democracy do we want this to be a democratic society?” – Noam Chomsky, Media Control.
Packer, Randall
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Bridging All-Photonic and Memory-Based Quantum Repeaters

open access: yesIEEE Transactions on Quantum Engineering
The all-photonic quantum repeater scheme based on repeater graph states (RGSs) offers a promising approach for constructing quantum networks without relying on long-coherence-time quantum memories, which remain a significant technological challenge ...
Naphan Benchasattabuse   +2 more
doaj   +1 more source

Resilience of Hyperlocal Media in a Global Media Environment

open access: yes
In this chapter, we present an overview of hyperlocal media business models in a global media environment. Our aim is to analyze operational rationales, with a specific focus on long-term survival and resilience.
Tenor, Carina,   +5 more
core   +1 more source

Critical media literacy among International Baccalaureate Diploma Programme graduates [PDF]

open access: yes, 2018
The amount of media is increasing and expanding, and various media and technology literacy skills can be essential in the global and technological societies.
Eskelinen, Mona
core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Perceived vibrato and the singing power ratio explain overall evaluations in opera singing

open access: yesFrontiers in Psychology
In opera singing competitions, judges use an overall score to evaluate the singers' voices and determine their rankings. This score not only guides the singers' technique and expressiveness but also serves as a crucial indicator that can significantly ...
Haruka Kondo   +4 more
doaj   +1 more source

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