Results 131 to 140 of about 1,079,714 (313)

Digital Australians: expectations about media content in a converging media environment

open access: yes, 2011
Digital Australians examines the impact of the increasing use of digital media on attitudes and expectations about media content and regulation across different media platforms.
Australian Communications and Media Authority
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

open access: yesFEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart   +7 more
wiley   +1 more source

Behavioral fluctuation reflecting theta-rhythmic activation of sequential working memory

open access: yesScientific Reports
Sequential working memory, the ability to actively maintain sequential information, is essential for human cognition. The neural representation of each item in sequential working memory is thought to be activated rhythmically within the theta (3–7 Hz ...
Takuya Ideriha, Junichi Ushiyama
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Switching on the behavioral and neural rhythmicity to retrieve memories when the number of retained items exceeds four

open access: yesScientific Reports
Does our nervous system rely on the same neural mechanism for memory retrieval across all contexts? Here, we report an intriguing phenomenon where the nervous system “switches on” behavioral and neural rhythms under specific conditions, such as when the ...
Takuya Ideriha, Junichi Ushiyama
doaj   +1 more source

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