Results 81 to 90 of about 298,833 (265)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

On the solvability of the integral electric field equation for nonabsorbing media

Известия высших учебных заведений. Поволжский регион: Физико-математические науки
Background. The problem of solvability of the electric field integral equation for non-absorbing media is considered. Materials and methods. The method of quadratic forms is applied to investigation of the operators of the problem.
Yuriy G. Smirnov
doaj   +1 more source

Regularity criteria of supercritical beta-generalized quasi-geostrophic equations in terms of partial derivatives

Electronic Journal of Differential Equations, 2013
We study the two-dimensional beta-generalized supercritical quasi-geostrophic equation, and in particular show that to obtain global regularity results, one needs to bound only its partial derivative.
Kazuo Yamazaki
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

One- and two-dimensional analytical solutions of the fractional Richards equation for testing numerical solvers

Partial Differential Equations in Applied Mathematics
This study provides analytical solutions of the fractional Richards equation for modeling water subdiffusion in porous media. Our aim is to provide some nontrivial analytical solutions which can serve as benchmark references to test numerical methods for
Radoine Belkanoufi, Abdelaziz Beljadid, Ahmed Taik   +2 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Soliton Dynamics of the Nonlinear Kodama Equation with M-Truncated Derivative via Two Innovative Schemes: The Generalized Arnous Method and the Kudryashov Method

Fractal and Fractional
The primary aim of this research article is to investigate the soliton dynamics of the M-truncated derivative nonlinear Kodama equation, which is useful for optical solitons on nonlinear media, shallow water waves over complex media, nonlocal internal ...
Khizar Farooq, Ali. H. Tedjani, Zhao Li, Ejaz Hussain   +3 more
doaj   +1 more source

Maxwell's Equations in Media and Their Solution

, 2016
10 pages, 2 figures, 2 ...
openaire   +2 more sources