Results 41 to 50 of about 39,061 (262)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Conservative media media-frames
Obraz, 2019 Introduction. Media researchers are still worried about the quality of journalism, the presence or absence of quality journalistic texts. It can be argued that the problem of the quality of journalism in various aspects seems to have won a central place in academic debate. Topicality. Goal.
openaire +1 more source
Islamic Communication JournalOne of the prolonged conflicts between Palestine and Israel has yet to find a solution. This study aims to explore Indonesian online media in framing news about the Palestinian-Israeli conflict during the Hamas attack on October 7, 2023.
Malik Ibrahim +4 more
doaj +1 more source
Strategic media framing and attributive agenda
Вестник Самарского университета: История, педагогика, филология, 2023 The focus of the analysis lies on the deconstruction of media messages in mass media discourse. The justification of approaches to promote the strategic media framing explains the implementation potential of media texts through linguo-cognitive, genre ...
A. G. Pastukhov
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Bingkai “Tampang Boyolali “ dalam Pidato Prabowo Subianto di Media Daring
Kalijaga Journal of Communication, 2019 This article aims to explain and describe "tampang Boyolali" in Prabowo's speech which was explored using online media framing analysis. To see the framing of media online the authorused qualitative research method with framing analysis Robert N Entman ...
Mike Meiranti
doaj +1 more source
Molecular Oncology, EarlyView.Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani +9 more
wiley +1 more source