Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Il lavoro freelance: reputazione e capitale sociale nell’era del “lavoro digitale”
This article presents the results of a qualitative research on freelance work in the context of the professions of the knowledge economy conducted between 2012 and 2013 across Milan and London.
Alessandro Gandini
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Freelance journalism in the 21st century: Challenges and opportunities [PDF]
This study examined Australian freelance journalists' careers and their role in the 21st century news industry. It discovered the skills, working life and professional identity of freelance journalists continue to be shaped by an industry undergoing ...
Templeman, Tiana L.
core
INTERVIEW: Jo Chandler: Gender, human rights and power investigations in Papua New Guinea
INTERVIEW: A series of stories on the complexity and contradictions of Papua New Guinea, Australia’s closest neighbour, has won the 2013 George Munster award for independent journalism.
Jo Chandler, Tom Morton
doaj +1 more source
Online Allies and Tricky Freelancers: Understanding the Differences in the Role of Social Media in the Campaigns for the Scottish Independence Referendum [PDF]
Using the 2014 Scottish independence referendum as a case study, this article asks first, to what extent is the use of digital communications technologies, in particular social media, associated with fundamental changes to campaign organizations, specifically to the command and control model?
Langer, Ana Ines +2 more
openaire +1 more source
Peran Digital Freelancer Marketplace dan Media Sosial Terhadap Perkembangan Gig Economy Worker
The Gig Economy Worker phenomenon is becoming an option for Generation Z to work; the problems that occur are the lack of attention from the Government in providing good guarantees for Gig Economy Workers, so it is necessary to conduct research that has the objective of How to Form Government Attention in Providing Social Security and Protection for ...
Kadek Masakazu Masakazu +3 more
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Background Creative methods/practices have been highlighted as helpful to develop more collaborative, equitable research partnerships between researchers and communities/public-participants.
Alice Malpass +7 more
doaj +1 more source

