Results 121 to 130 of about 17,178,928 (281)

The Netherlands

, 2021
Vandenberghe, Hanne, d'Haenens, Leen
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Foreign correspondence from Sub-Saharan Africa: An evolving communicational paradigm shift / Corresponsales extranjeros en África Subsahariana: Un paradigma comunicativo en evolución

Index Comunicación, 2013
A sizable portion of our everyday knowledge about Sub-Saharan Africa comes from the work of international news reporters. Even though these news actors play a critical role in the communication of the distant Other, frequently criticized for its ...
Paulo Nuno Vicente, Universidade Nova de Lisboa   +1 more
doaj  

Dans l’atelier de la chercheuse

Sur le Journalisme
FR. Cet article examine les choix méthodologiques posés dans le cadre d’une étude sur les violences et les expériences d’insécurité vécues par les journalistes francophones en Belgique. J’y explique comment mes postures d’ex-pigiste, mais aussi de femme,
Clémence Petit
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

AI-Powered Campaign Management: The Future of Freelance Media Buying

AI-Powered Campaign Management: The Future of Freelance Media Buying examines how artificial intelligence is transforming the way freelance media buyers manage digital advertising campaigns. It highlights how tools like Smart Bidding, automation scripts, and AI-driven creatives enable solo professionals to deliver agency-level results, scale operations
openaire   +1 more source

PERSONAL BRANDING OF FREELANCE MAKE UP ARTIST (MUA) IN PEKANBARU CITY ON INSTAGRAM SOCIAL MEDIA

Jurnal Netnografi Komunikasi
Searching for MUA services in the digital era is now easy, with many choices on social media such as Instagram, which allows searches based on domicile, price, characteristics or quality. This research aims to analyze the personal branding of freelance MUAs in Pekanbaru via Instagram, using Montoya's personal branding theory with eight indicators ...
null Suci Shinta Lestari, null Mutia Farina   +1 more
openaire   +1 more source