Results 91 to 100 of about 17,178,928 (281)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Liveness Redux: On Media and Their Claim to be Live [PDF]

, 2017
Increasingly media are asserting themselves as live. In television, this has been an important strategy and recently it has been employed by new media platforms such as Facebook, Periscope and Snapchat.
van Es, K.F., ICON - Media and Performance Studies, LS Media en Communicatie, Karin van Es   +3 more
core   +1 more source

A vision for responsible AI integration in citizen science

Humanities & Social Sciences Communications
The integration of Artificial Intelligence (AI) into Citizen Science (CS) is transforming how communities collect, analyze, and share data, offering opportunities for enhanced efficiency, accuracy, and scalability of CS projects.
Maryam Lotfian, Christophe Claramunt, Anna Berti Suman, Andres Perez-Uribe, Nicolas Chavent, Olivier Ertz, Jens Ingensand   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Medya endüstrisinde serbest (freelance) gazetecilerin işgücü piyasası analizi [PDF]

, 2019
06.03.2018 tarihli ve 30352 sayılı Resmi Gazetede yayımlanan “Yükseköğretim Kanunu İle Bazı Kanun Ve Kanun Hükmünde Kararnamelerde Değişiklik Yapılması Hakkında Kanun” ile 18.06.2018 tarihli “Lisansüstü Tezlerin Elektronik Ortamda Toplanması ...
Çiğdem, Serpil
core   +1 more source

Fansubbing del español al chino : organización, roles y normas en la escritura colaborativa

BiD: Textos Universitaris de Biblioteconomia i Documentació, 2016
Objetivo: documentar y analizar la cooperación en línea de una comunidad digital que subtitula series y películas hispanas al chino, estudiando los roles y las funciones, la cadena de trabajo, los espacios virtuales, las estrategias de autorregulación y ...
Zhang, Tian Leticia, Cassany, Daniel
doaj   +1 more source

The price of freedom: the opportunities and constraints of freelance employment for older workers : a study of media professionals [PDF]

, 2002
The UK's population is ageing at a time when its oldest workers are leaving the labour market at progressively younger ages. This paradox - of declining economic activity rates among the 50 plus age group and rising longevity - has led to widespread concern over the social and economic consequences . Meanwhile, flexible work has grown in the UK economy
openaire   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Translations| “The Task of the Translator”: Comparing the Views of the Client and the Translator

International Journal of Communication, 2016
As a consequence of globalization and corporate restructuring processes, most translators are now freelance and generally work for multiple clients on a project basis.
Hanna Risku, Christina Pein-Weber, Jelena Milosevic   +2 more
doaj