Results 41 to 50 of about 15,270 (270)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Pekerja Lepas (Freelancer) dalam Dunia Bisnis [PDF]

open access: yes, 2018
Studi ini hendak mendeskripsikan bagaimana pengaruh perkembangan teknologi informasi dan komunikasi di dalam dunia bisnis, terutama kehadiran pekerja lepas (freelance) yang akhir-akhir ini makin mudah dijumpai. Sebagai bagian dari dunia bisnis, kehadiran
MUSTOFA, M. (MUSTOFA)
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

An Essential Guide to Online Freelancing [PDF]

open access: yes, 2015
The purpose of the thesis was to introduce the readers to the phenomenon of online freelancing from an entrepreneurial point of view, alongside providing an up-to-date guide to undergraduate student about how to become a freelancer in general manners ...
Novits, Janos
core  

Hiring and Learning in Online Global Labor Markets [PDF]

open access: yes, 2011
This paper uses data from freelancer.com – an online platform that allows employers and freelancers to search for, and match with, each other – to study the effect of freelancers’ country of origin on their likelihood to be hired ...
Mill, Roy
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The Brighton Fuse 2. Freelancers in the creative digital IT economy [PDF]

open access: yes, 2015
No description ...
Camerani, Roberto   +5 more
core   +1 more source

The politics of journalistic creativity: expressiveness, authenticity and de-authorization [PDF]

open access: yes, 2012
This article begins with the assertion that creativity in journalism has moved from being a matter of guile and ingenuity to being about expressiveness, and that this reflects a broader cultural shift from professional expertise to the authenticity of ...
Markham, Tim
core   +1 more source

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