Results 51 to 60 of about 15,270 (270)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Multiplication des statuts précaires et (dé)structuration de l’espace professionnel

Sur le Journalisme, 2013
Cet article vise à interroger les formes d’encadrement du marché du travail du journalisme, la diversification des statuts d’emploi qui y ont cours et ses effets sur l’espace professionnel.
Cégolène Frisque
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

How open are journalists on Twitter? Trends towards the end-user journalism [PDF]

, 2013
The many activities of journalists on Twitter should be analyzed. Are they doing a different kind of journalism? With a content analysis of 1125 tweets, this study reveals trends of some Spanish journalists using Twitter.
Noguera-Vivo, José-Manuel
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Entgrenzung als allgemeinerer Trend? Mobile Pflege und Arbeit in der Medien- und Kulturindustrie im Vergleich [PDF]

, 2005
In der deutschsprachigen Arbeits- und Industriesoziologie wird derzeit eine intensive Debatte über die Entgrenzung von Erwerbsarbeit geführt. Hiermit ist gemeint, dass sich die industriegesellschaftlich etablierten Grenzen von Erwerbsarbeit verflüssigen ...
Henninger, Annette, Papouschek, Ulrike
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Freelance Articles and Electronic Databases: Who Owns the Copyrights? [PDF]

, 2001
There has long been uncertainty as to who owns the rights to digital reproductions of freelance articles. The Supreme Court has recently affirmed that copyrights for the digital reproduction of freelance articles belong to freelance authors, rather than ...
Soares, Christine
core   +1 more source

Freelance working: Mobile technology and social media

, 2017
Freelance workers are important contributors to the United Kingdom’s (UK) economy and they are growing significantly not at least because technology enables them to work on their own account. Reports based on Labour Force Survey (LFS) data estimate that there were 1.9 million freelance workers in the UK in 2015, constituting 6% of all UK workers in ...
Reuschke, Darja, Wilkins, Annabelle H.
openaire   +1 more source