Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Drifting Apart? European Journalists and Their Audiences [PDF]
, 2008 How do the current technological changes and socio-political developments impact on the relationship between European journalists and their audiences?
Metykova, Monika
core +2 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Digital and Mobile Security for Mexican Journalists and Bloggers [PDF]
, 2013 A new survey of 102 journalists and bloggers in 20 Mexican states shows nearly 70 percent have been threatened or have suffered attacks because of their work. In addition, 96 percent say they know of colleagues who have been attacked.
Jorge Luis Sierra
core
The Dark Side of Micro-Task Marketplaces: Characterizing Fiverr and Automatically Detecting Crowdturfing [PDF]
, 2014 As human computation on crowdsourcing systems has become popular and powerful for performing tasks, malicious users have started misusing these systems by posting malicious tasks, propagating manipulated contents, and targeting popular web services such ...
Ge, Hancheng, Lee, Kyumin, Webb, Steve
core +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
From commercial marketing to electoral marketing: candidates’ attributes in the perception of Brazilian and American voters [PDF]
, 2017 This study investigates attributes that influence the vote in different socioeconomic contexts (Brazil/USA). Our results show an asymmetric effect of candidates’ attributes on voters’ decision.
Mainardes, Emerson +3 more
core
Locking Out the Mother Corp: Nationalism and Popular Imaginings of Public Service Broadcasting in the Print News Media [PDF]
, 2007 Early promoters of public-service broadcasting (PSB) in Canada emphasized its democratic and nationalist merit. Of these twin pillars, only nationalism appears to still be standing.
Ferguson, Sue
core +3 more sources
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source