Results 71 to 80 of about 2,807,409 (305)
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Freelance working: Mobile technology and social media
, 2017 Freelance workers are important contributors to the United Kingdom’s (UK) economy and they are growing significantly not at least because technology enables them to work on their own account. Reports based on Labour Force Survey (LFS) data estimate that there were 1.9 million freelance workers in the UK in 2015, constituting 6% of all UK workers in ...
Reuschke, Darja, Wilkins, Annabelle H.
openaire +1 more source
Hiring and Learning in Online Global Labor Markets [PDF]
, 2011 This paper uses data from freelancer.com – an online platform that allows employers and freelancers to search for, and match with, each other – to study the effect of freelancers’ country of origin on their likelihood to be hired ...
Mill, Roy
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Digital and Mobile Security for Mexican Journalists and Bloggers [PDF]
, 2013 A new survey of 102 journalists and bloggers in 20 Mexican states shows nearly 70 percent have been threatened or have suffered attacks because of their work. In addition, 96 percent say they know of colleagues who have been attacked.
Jorge Luis Sierra
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
VADER: A Parsimonious Rule-Based Model for Sentiment Analysis of Social Media Text
International Conference on Web and Social Media, 2014 The inherent nature of social media content poses serious challenges to practical applications of sentiment analysis. We present VADER, a simple rule-based model for general sentiment analysis, and compare its effectiveness to eleven typical state-of-
C. J. Hutto, Eric Gilbert
semanticscholar +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Employment and Working Conditions of Selected Types of Platform Work [PDF]
, 2018 Platform work is a form of employment that uses an online platform to match the supply of and demand for paid labour. In Europe, platform work is still small in scale but is rapidly developing.
de Groen, Willem Pieter +3 more
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source